High concentrations of N-BNP are related to non-infectious severe SIRS associated with cardiovascular dysfunction occurring after off-pump coronary artery surgery

British Journal of Anaesthesia
F KerbaulF Gouin

Abstract

Procalcitonin (PCT) blood concentrations are known to be an appropriate marker of severe systemic inflammatory response syndrome (SIRS) induced by coronary artery surgery with and without cardiopulmonary bypass. Pro-brain natriuretic peptide (N-BNP) is a newly described cardiac hormone considered to be an effective marker of severity and prognosis of acute coronary syndromes and congestive heart failure. We evaluated the perioperative time courses of PCT and N-BNP and investigated their role as early markers of severe SIRS (SIRS with cardiovascular dysfunction) induced by off-pump coronary artery bypass (OPCAB). Sixty-three patients were prospectively included. The American College of Chest Physicians Classification was used to diagnose SIRS and organ system failure to define severe SIRS. Serum concentrations of PCT and N-BNP were determined before, during and after surgery. Receiver operating characteristic curves and cut-off values were used to assess the ability of these markers to predict postoperative severe SIRS. SIRS occurred in 25 (39%) patients. Nine of them (14%) showed severe SIRS. Significantly higher serum concentrations of N-BNP and PCT were found in patients with severe SIRS with peak concentrations respectively ...Continue Reading

References

Oct 1, 1991·Canadian Journal of Physiology and Pharmacology·K NakaoH Imura
Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S A NashefR Salamon
Feb 16, 2000·British Journal of Anaesthesia·A AouifiJ J Lehot
Oct 6, 2001·The New England Journal of Medicine·J A de LemosE Braunwald

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Citations

Oct 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Christoph SponholzFrank Brunkhorst
Sep 16, 2008·Critical Care : the Official Journal of the Critical Care Forum·Chlodwig KirchhoffPeter Biberthaler
Jul 17, 2010·Cardiology Research and Practice·C MüllerR Buchhorn
Jul 9, 2008·Scandinavian Cardiovascular Journal : SCJ·Minxin WeiMatti Tarkka
Feb 11, 2016·Journal of Critical Care·María Heredia-RodríguezEduardo Tamayo
Jul 14, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Crespo-MarcosD Pérez-Solís
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Rowan WalshKaie Ojamaa
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Judith VillacortaCatherine Guidon
Dec 1, 2007·Journal of Intensive Care Medicine·Mohamed Y Rady

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