High concentrations of plasma immunoreactive inhibin during normal pregnancy in women

The Journal of Clinical Endocrinology and Metabolism
Y AbeM Igarashi

Abstract

The plasma inhibin concentrations in 190 normal pregnant women at 5-40 weeks gestation and in 4 puerperal women were measured by a specific RIA for human inhibin. The average plasma inhibin concentrations in pregnant women throughout pregnancy (minimum, 2.25 +/- 0.48 IU/mL at 17 weeks gestation; maximum, 24.15 +/- 6.99 IU/mL at 39 weeks gestation) were much higher than those in nonpregnant women with a normal menstrual cycle (0.46 +/- 0.04 IU/mL in the midfollicular phase and 2.02 +/- 0.47 IU/mL in the midluteal phase). The inhibin concentrations were already high at 5 weeks gestation (7.54 +/- 1.10 IU/mL) and rose to peak at 8-10 weeks gestation. The concentrations then decreased and remained relatively low during 14-30 weeks gestation, but rose again during the third trimester. The inhibin concentrations decreased to undetectable levels after delivery. Immunoreactive inhibin was demonstrated in the corpus luteum and term placental extracts, and the dose-response curves were parallel to an inhibin preparation from human follicular fluid. Immunoreactive inhibin concentrations were also high in both the umbilical vein and artery (7.77 +/- 0.80 and 7.84 +/- 0.78 IU/mL, respectively). These observations suggest that both the corpu...Continue Reading

Citations

Feb 16, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J Qu, K Thomas
May 6, 1998·Histopathology·W G McCluggageJ M Sloan
Dec 21, 2002·Biology of Reproduction·Yumiko TanakaKazuyoshi Taya
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Oct 1, 1996·British Journal of Obstetrics and Gynaecology·E M Wallace, D L Healy
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May 20, 1998·Journal of Endocrinological Investigation·P FlorioF Petraglia
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