High concentrations of the CA-125, CA 19-9 and CA 15-3 in the peritoneal fluid between patients with and without endometriosis

Archives of Gynecology and Obstetrics
Ioannis M MatalliotakisEugenios E Koumantakis

Abstract

In the present study we compared the levels of CA-125, CA 19-9, and CA 15-3 in the peritoneal fluid (PF) of patients with and without endometriosis, then assessed the possibility of a correlation among these tumor markers. Our study was a controlled clinical study of patients undergoing laparoscopy for infertility or other benign gynecology conditions. Peritoneal fluid samples were collected from 65 women with endometriosis and 43 women without pelvic disease. Levels of CA-125, CA 19-9 and CA 15-3 in the peritoneal fluid were determined by immunoradiometric assay. The concentration of CA-125 in PF from patients with endometriosis was significantly higher than that in the control group (p<0.001); for CA 19-9 and CA 15-3, PF concentrations were not statistically different between these two groups. Women with endometriosis had significantly higher levels of CA-125 in proliferative and secretory phases than the control group (p<0.001 and p<0.002 respectively); furthermore, in patients with endometriosis the CA 19-9 levels were significantly lower in secretory phase than the proliferative (p<0.004). The levels of CA-125 were significantly lower in women with tubal ligation, in comparison with infertility or pelvic pain in the contro...Continue Reading

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Citations

Feb 4, 2014·Archives of Gynecology and Obstetrics·Abdullah TutenMahmut Oncul
Apr 14, 2009·Archives of Gynecology and Obstetrics·Caio Parente BarbosaGeraldo Rodrigues de Lima
Jul 15, 2015·Molecular Medicine Reports·Brett MckinnonNick A Bersinger
Mar 8, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Liang WangSu-Zhan Zhang
Apr 12, 2013·Molecular Reproduction and Development·Edson Guimarães Lo TurcoAgnaldo Pereira Cedenho
Jun 21, 2006·Fertility and Sterility·Ana Carolina Japur de Sá Rosa e SilvaRui Alberto Ferriani
Feb 25, 2014·Medical Hypotheses·K ToorW G Foster
Nov 7, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Vivian Ferreira do AmaralMarcos Dias de Moura
Aug 8, 2015·The Journal of International Medical Research·Airong ShenShunhong Zou
Jun 1, 2018·Reproductive Sciences·Jae Hoon LeeSung Hoon Kim
Jan 20, 2021·Analytica Chimica Acta·Thangapandi KalyaniSaikat Kumar Jana
Aug 28, 2021·Reproductive Biomedicine Online·See Ling LoyYie Hou Lee

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