PMID: 8610148Apr 2, 1996Paper

High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism

Proceedings of the National Academy of Sciences of the United States of America
S M SingerH O McDevitt

Abstract

To better understand the role of class II major histocompatibility complex molecules in both normal and autoimmune responses, we have produced a series of I-Ab transgenic mice. One of these transgenic constructs, designated NOD.PD, has the sequence of the NOD beta chain (Abeta(g7)) except at positions 56 and 57, where Pro-Asp replaces His-Ser. Several NOD.PD transgenic lines have been produced. One line of these mice carried a very high number of copies (>50) of the NOD.PD transgene. As has been described in other mice carrying high copy numbers of I-Ab transgenes, B-cell development was abnormal. The steady state numbers of mature B cells (IgM+/IgD(hi)) in the periphery were greatly reduced in transgenic mice compared to nontransgenic littermates. Surprisingly, rather than being accompanied by a generalized hypogammaglobulinemia, this B-cell deficiency was accompanied by elevated concentrations of IgG1 and IgE in the serum. Conversely, the levels of IgG2a were reduced in transgenic mice compared to nontransgenic littermates. Because this isotype pattern was characteristic of interleukin (IL)-4-induced class-switching, we then investigated the role of IL-4 in causing the observed phenotype. We crossed the high copy number trans...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·T J VasicekP Leder
Sep 1, 1992·The Journal of Clinical Investigation·M J Clare-SalzlerC Anderson
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
May 29, 1992·Cell·D KitamuraK Rajewsky
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S GilfillanH O McDevitt
Nov 1, 1991·Science·R KühnW Müller
Jun 15, 1990·Science·H von Boehmer, P Kisielow
Jun 15, 1990·Science·A A SinhaH O McDevitt
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S GilfillanH O McDevitt
Jun 1, 1990·Immunology Today·C H JuneC B Thompson
Dec 1, 1989·The Journal of Experimental Medicine·J S MurrayK Bottomly
Sep 1, 1989·The Journal of Experimental Medicine·J C Cambier, K R Lehmann
Sep 1, 1988·Immunology Today·K Bottomly
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G A Bishop, G Haughton
Sep 1, 1984·European Journal of Immunology·M Baniyash, Z Eshhar
Feb 10, 1983·Nature·G C BosmaM J Bosma
Jan 1, 1993·Immunology Today·D G Osmond
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L NitschkeM C Lamers
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A JakobovitsG R Otten

❮ Previous
Next ❯

Citations

Oct 21, 2011·Nucleic Acids Research·Tzachi BarAles Tichopad
Jan 13, 2000·Immunological Reviews·G SønderstrupH O McDevitt
Dec 11, 1999·Immunity·N LabrecqueD Mathis
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chad H Koonce, Elizabeth K Bikoff
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kamel BenlaghaAlbert Bendelac

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
S GilfillanH O McDevitt
International Journal of Clinical & Laboratory Research
S Sartoris, R S Accolla
© 2021 Meta ULC. All rights reserved