High correlation between genotypes and phenotypes of environmental bacteria Comamonas testosteroni strains

BMC Genomics
Lin LiuMeizhong Luo

Abstract

Members of Comamonas testosteroni are environmental microorganisms that are usually found in polluted environment samples. They utilize steroids and aromatic compounds but rarely sugars, and show resistance to multiple heavy metals and multiple drugs. However, comprehensive genomic analysis among the C. testosteroni strains is lacked. To understand the genome bases of the features of C. testosteroni, we sequenced 10 strains of this species and analyzed them together with other related published genome sequences. The results revealed that: 1) the strains of C. testosteroni have genome sizes ranging from 5.1 to 6.0 Mb and G + C contents ranging from 61.1% to 61.8%. The pan-genome contained 10,165 gene families and the core genome contained 3,599 gene families. Heap's law analysis indicated that the pan-genome of C. testosteroni may be open (α = 0.639); 2) by analyzing 31 phenotypes of 11 available C. testosteroni strains, 99.4% of the genotypes (putative genes) were found to be correlated to the phenotypes, indicating a high correlation between phenotypes and genotypes; 3) gene clusters for nitrate reduction, steroids degradation and metal and multi-drug resistance were found and were highly conserved among all the genomes of thi...Continue Reading

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Citations

Oct 14, 2016·Scientific Reports·Yi-Lung ChenYin-Ru Chiang
Feb 17, 2017·Case Reports in Gastroenterology·Shaika FarooqNahida Nahvi
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Methods Mentioned

BETA
PCA

Software Mentioned

illumina
RAST
OrthoMCL
Prokaryotic Genome Annotation Server ( RAST )
MEGA6
AWOR00000000
blastp
AWOV00000000
blast
Clustal W

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