High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content

PeerJ
Wen-Shyan HuangNiann-Tzyy Dai

Abstract

To treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select the optimal donor skin to achieve a desired color match. Determining the correlations with the desired skin color measurement based on CIELAB color, epidermal melanocyte numbers, and melanin content of individual melanocytes is critical for clinical application. Fifteen foreskin samples from Asian young adults were analyzed for skin color, melanocyte ratio (melanocyte proportion in the epidermis), and melanin concentration. Furthermore, an equation was developed based on CIELAB color with melanocyte ratio, melanin concentration, and the product of melanocyte ratio and melanin concentration. The equation was validated by seeding different ratios of keratinocytes and melanocytes in tissue-engineered skin substitutes, and the degree of fitness in expected skin color was confirmed. Linear regression analysis revealed a significant strong negative correlation (r =  - 0.847, R2 = 0.717) between CIELAB L* value and the product of the epidermal melanocyte ratio and cell-based melanin concentration. Furthermore, the r...Continue Reading

References

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Citations

Jul 15, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Toktam KhatibiMehdi Totonchi
Jul 2, 2019·Biomedical Optics Express·Xomalin G PeraltaIbtissam Echchgadda
Jun 17, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jade G M LoggerPiet E J van Erp
Nov 5, 2020·Scientific Reports·Abayomi T OgunjimiNicole K Brogden

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Methods Mentioned

BETA
circumcision
Fluorescent-activated cell sorting
flow cytometry
FACS

Software Mentioned

CIELAB
SPSS
Statistical Package for the Social Sciences
Statistical Product and Service Solutions ( SPSS )
CellQuest

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