High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Jorge L SepulvedaAntonia R Sepulveda

Abstract

Gastric cancers are the most frequent gastric malignancy and usually arise in the sequence of Helicobacter pylori-associated chronic gastritis. CpG methylation is a central mechanism of epigenetic gene regulation affecting cancer-related genes, and occurs early in gastric carcinogenesis. DNA samples from non-metaplastic gastric mucosa with variable levels of gastritis (non-metaplastic mucosa), intestinal metaplasia, or gastric cancer were screened with methylation arrays for CpG methylation of cancer-related genes and 30 gene targets were further characterized by high-definition bisulfite next-generation sequencing. In addition, data from The Cancer Genome Atlas were analyzed for correlation of methylation with gene expression. Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN). Further, most of these genes had corresponding reduced expression levels in gastric cancer compared with intestinal metaplasia, including novel hypermethylated genes in gastric cancer (FLI1, GALR1, SGCE, and SNRPN), suggesting that they may regulate neoplastic transformation from non-malignant intestinal m...Continue Reading

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Citations

Aug 18, 2016·Helicobacter·Steffen BackertMichael Naumann
Sep 10, 2019·Cancer Cell International·Jingyue SunShuang Liu
Jul 28, 2020·Advanced Science·Lina ZhaoBaowei Jiao
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Jun 30, 2021·Biochemical and Biophysical Research Communications·Shubhashish Chakraborty, Ashok K Varma
Nov 13, 2021·Journal of Gastrointestinal Cancer·Fatima BoubrikNadia El Kadmiri

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