High definition-transcranial direct current stimulation changes older adults' subjective sleep and corresponding resting-state functional connectivity

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
Jing ShengJing Yu

Abstract

With advanced age, older adults show functional deterioration in sleep. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation, modulates individuals' behavioral performance in various cognitive domains. However, the modulation effect and neural mechanisms of tDCS on sleep, especially for the elderly population are not clear. Here, we aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) could modulate community-dwelling older adults' subjective sleep and whether these potential improvements are associated with the large-scale brain activity alterations recorded by functional magnetic resonance imaging. Thirty-one older adults were randomly allocated to the HD-tDCS group and the control group. HD-tDCS was applied for 25 min at 1.5 mA per day for two weeks. The anode electrode was placed over the left dorsolateral prefrontal cortex, surrounded by 4 cathodes at 7 cm radius. All participants completed sleep neuropsychological assessments and fMRI scans individually before and after intervention. Behaviorally, we observed a HD-tDCS-induced enhancement of older adults' sleep duration. On the aspect of the corresponding neural alterations, we observed that HD-tDCS decr...Continue Reading

Citations

Aug 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea N Goldstein-PiekarskiLeanne M Williams
Nov 15, 2019·Journal of American College Health : J of ACH·Jonathan CharestCelyne H Bastien
Jun 25, 2021·Frontiers in Psychiatry·Clément DondéPierre A Geoffroy

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