High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons

The Journal of Physiology
Dominique Engel, Vincent Seutin

Abstract

The hyperpolarization-activated cation current Ih is expressed in dopamine neurons of the substantia nigra, but the subcellular distribution of the current and its role in synaptic integration remain unknown. We used cell-attached patch recordings to determine the localization profile of Ih along the somatodendritic axis of nigral dopamine neurons in slices from young rats. Ih density is higher in axon-bearing dendrites, in a membrane area close to the axon origin, than in the soma and axon-lacking dendrites. Dual current-clamp recordings revealed a similar contribution of Ih to the waveform of single excitatory postsynaptic potentials throughout the somatodendritic domain. The Ih blocker ZD 7288 increased the temporal summation in all dendrites with a comparable effect in axon- and non-axon dendrites. The strategic position of Ih in the proximity of the axon may influence importantly transitions between pacemaker and bursting activities and consequently the downstream release of dopamine. Dendrites of most neurons express voltage-gated ion channels in their membrane. In combination with passive properties, active currents confer to dendrites a high computational potential. The hyperpolarization-activated cation current Ih pres...Continue Reading

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Citations

Nov 11, 2016·Journal of Neurophysiology·Francisco Arencibia-AlbiteCarlos A Jiménez-Rivera
Sep 2, 2016·Journal of Neurophysiology·Carmen C CanavierBoris S Gutkin
Aug 14, 2018·The European Journal of Neuroscience·Lilach GorodetskiAlon Korngreen
Jun 28, 2016·Stem Cells Translational Medicine·Douglas A GrowChristopher S Navara
Sep 24, 2019·PLoS Computational Biology·Timothy Rumbell, James Kozloski
Jun 25, 2019·Frontiers in Molecular Neuroscience·Xiaoli ChangJunxia Xie
Jun 29, 2021·Progress in Biophysics and Molecular Biology·Crescent L Combe, Sonia Gasparini
Mar 27, 2021·Annual Review of Neuroscience·Jean-Marc Goaillard, Eve Marder
Aug 30, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Karl Y Bosque-CorderoCarlos A Jimenez-Rivera

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