High density analysis of randomly selected Neurospora octads reveals conversion associated with crossovers located between cog and his-3

Fungal Genetics and Biology : FG & B
P J YeadonD E Catcheside

Abstract

We analysed 148 octads from a Neurospora cross maximised for sequence heterology in the his-3 region and detected non-Mendelian segregation at his-3, cot-1 and lys-4 loci. This was in all cases 6:2 or 2:6, with no evidence of post-meiotic segregation (PMS) in these genes. High density snp analysis was used to place crossovers between his-3 and the centromere-distal marker ad-3, and sequencing to refine the location of crossovers between his-3 and the recombination hotspot cog. Crossovers appeared to have a non-random distribution, falling close to his-3 or more than 40 kb distal, and all those in which the location was determined were flanked by sequences showing gene conversion and/or PMS amongst the polymorphisms. This octad study confirms the validity of assumptions made during random spore analyses and suggests that recombination hotspots at cot-1 and lys-4 may, unlike the relatively cold recombination initiator at the am locus, be high frequency recombinators similar to cog.

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Citations

Dec 29, 2011·Molecular Genetics and Genomics : MGG·P J YeadonD E A Catcheside
Jun 14, 2012·Fungal Genetics and Biology : FG & B·Frederick J BowringDavid E A Catcheside

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