High-density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners

The New England Journal of Medicine
P T Williams

Abstract

Official guidelines from the Centers for Disease Control and Prevention assert that the majority of health benefits from physical activity are obtained by walking 2 miles (3.2 km) briskly most days of the week (the energy equivalent of running 8 to 12 km per week). The objective of our study was to examine the dose-response relation in women between risk factors for coronary heart disease, particularly the concentration of high-density lipoprotein (HDL) cholesterol, and vigorous exercise at levels that exceed the official guidelines. The number of kilometers run per week reported by 1837 female recreational runners in a national cross-sectional survey was compared with medical data provided by the women's physicians. In these cross-sectional data, plasma HDL cholesterol concentrations were higher by an average (+/- SE) of 0.133 +/- 0.020 mg per deciliter (0.003 +/- 0.0005 mmol per liter) for every additional kilometer run per week, an amount nearly identical with that previously reported for men (0.136 +/- 0.006 mg per deciliter [0.004 +/- 0.0002 mmol per liter] per kilometer per week). Among women who ran less than 48 km per week, mean plasma HDL concentrations were significantly higher with each 16-km increment in distance. W...Continue Reading

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