High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program

American Journal of Epidemiology
J D CurbKatsuhiko Yano

Abstract

High density lipoprotein (HDL) cholesterol has been inversely associated with coronary heart disease. Associations with stroke are less clear, particularly among the elderly. In this study, the authors examined the relation between HDL cholesterol levels and the risk of stroke in elderly men. Levels of HDL cholesterol were measured in 2,444 Honolulu Heart Program men aged 71-93 years at the 1991-1993 examinations. The participants, who were free of prevalent stroke, coronary heart disease, and cancer at baseline, were followed to the end of 1998 for thromboembolic and hemorrhagic stroke. While HDL cholesterol was unrelated to hemorrhagic events, incidence of thromboembolic stroke declined consistently with increasing HDL cholesterol level (p = 0.003). There was a nearly threefold excess of thromboembolic stroke in men with low HDL cholesterol levels (<1.0 mmol/liter (<40 mg/dl)) compared with men with high levels (> or =1.6 mmol/liter (> or =60 mg/dl)) (10.6/1,000 person-years vs. 3.6/1,000 person-years; p = 0.001). Adjustment for other risk factors had little effect on these findings, although associations appeared strongest in elderly men with "desirable" total cholesterol levels, hypertension, or diabetes mellitus. These fin...Continue Reading

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References

Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P ZimetbaumH A Eder
Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Aug 8, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Aug 1, 1990·The Journal of Clinical Investigation·A R Tall
Nov 9, 1989·The New England Journal of Medicine·D J Gordon, B M Rifkind
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R D AbbottW P Castelli
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·G W CockerillP J Barter
Aug 16, 1995·JAMA : the Journal of the American Medical Association·M C CortiC H Hennekens
Nov 1, 1994·Journal of Gerontology·P W WilsonW P Castelli
May 1, 1994·American Journal of Epidemiology·R D AbbottJ D Curb
Jun 1, 1994·Stroke; a Journal of Cerebral Circulation·A KaganJ S Grove
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·L A SimonsJ Simons
Dec 2, 1999·Journal of Clinical Epidemiology·A A HakimR D Abbott
Aug 6, 2000·Stroke; a Journal of Cerebral Circulation·S G WannametheeS Ebrahim
Sep 23, 2000·Nature·A J Lusis
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
May 26, 2001·The American Journal of Cardiology·D L Sprecher
Jun 21, 2001·JAMA : the Journal of the American Medical Association·R L SaccoL Berglund
Sep 29, 2001·Journal of Clinical Epidemiology·R D AbbottJ D Curb
Jun 5, 2003·Journal of Clinical Pathology·K M SheehanA Grace
Nov 15, 2003·Stroke; a Journal of Cerebral Circulation·Thomas S BowmanJ Michael Gaziano

❮ Previous
Next ❯

Citations

Nov 11, 2009·Archives of Neurology·Joshua Z WilleyMitchell S V Elkind
Sep 6, 2006·Biogerontology·Stavroula KanoniEugenio Mocchegiani
Jan 5, 2008·Current Atherosclerosis Reports·Larry B Goldstein
Jan 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gösta FlorvallAnders Larsson
Jan 16, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·K LipskaK Radhakrishnan
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·José Rafael RomeroAleksandra Pikula
Nov 23, 2010·Drugs & Aging·Joseph E ThomasJoAnne M Foody
Sep 13, 2014·Drugs & Aging·Martinson K ArnanCheryl Bushnell
Dec 19, 2008·Current Cardiology Reports·Babak B Navi, Alan Z Segal
Sep 12, 2012·Current Cardiology Reports·Ian GrahamZeljko Reiner
Feb 7, 2012·The American Journal of Emergency Medicine·Sion JoBoyoung Park
Mar 8, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Takahiro KuwashiroMitsuo Iida
Apr 27, 2010·Archives of Gerontology and Geriatrics·Elizabete Viana de FreitasAyrton Pires Brandão
Jun 9, 2009·Clinical Biochemistry·Reza Meshkani, Khosrow Adeli
Apr 1, 2009·Journal of Clinical Lipidology·Sunita DodaniSunil Joshi
Feb 16, 2006·Journal of Internal Medicine·G WalldiusI Jungner
Dec 2, 2008·CNS Neuroscience & Therapeutics·Adrienne Keener, Nerses Sanossian
Dec 6, 2012·Stroke Research and Treatment·Silvia Di LeggeFabrizio Sallustio
May 26, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Diana R ChirovskyPhilip Barter
Sep 12, 2016·The American Journal of Emergency Medicine·Seunghun OckBoyoung Park
Apr 11, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yujie LiLing Gao
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 30, 2006·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 17, 2008·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 17, 2010·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 7, 2013·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandUNKNOWN Council on Functional Genomics and Translational Biology
Sep 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Renske G WieberdinkM Arfan Ikram
May 28, 2011·Stroke; a Journal of Cerebral Circulation·Salvador Cruz-FloresUNKNOWN Council on Quality of Care and Outcomes Research
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 27, 2007·Stroke; a Journal of Cerebral Circulation·Nerses SanossianBruce Ovbiagele
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jun 9, 2007·Current Opinion in Cardiology·Göran Walldius, Ingmar Jungner
Apr 10, 2008·Journal of Hypertension·Dimitris P Papadopoulos, Vasilios Papademetriou
Dec 6, 2005·Cerebrovascular Diseases·José Vivancos-Mora, Antonio C Gil-Núñez
Apr 15, 2009·Expert Opinion on Pharmacotherapy·Vasilios Papademetriou, Michael Doumas

❮ Previous
Next ❯

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