High-density lipoprotein cholesterol and objective measures of lower extremity performance in older nondisabled persons: the InChianti study.

Journal of the American Geriatrics Society
S VolpatoJack Guralnik

Abstract

To evaluate the independent association between high-density lipoprotein cholesterol (HDL-C) levels and objective measures of lower extremity performance. Cross-sectional cohort study. Community-based. Eight hundred thirty-six nondisabled women and men aged 65 and older enrolled in the Invecchiare in Chianti study. Lower extremity performance was assessed using 4-m walking speed at fast pace, 400-m walking speed, and knee extension torque. Fasting HDL-C levels were determined using commercial enzymatic tests. The mean age of participants was 73.7 (65-92), and 55.6% were women. After adjusting for potential confounders (sociodemographic factors, smoking, physical activity, body composition, and clinical conditions including cardiovascular and cerebrovascular disease, inflammatory markers, and serum testosterone) HDL-C levels were significantly associated with knee extension torque in men and women and with 4-m and 400-m walking speed in men. Men in the highest tertile of the HDL-C distribution (>55 mg/dL) had, on average, a three times greater probability of belonging to the best tertile of all indexes of lower extremity performance, including 4-m fast walking speed (odds ratio (OR)=2.57, 95%=confidence interval (CI)=1.07-6.17),...Continue Reading

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Citations

Aug 21, 2013·Zeitschrift für Gerontologie und Geriatrie·M Lechleitner
Jun 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eric BrunnerMichael Marmot
Sep 24, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stefano VolpatoJack M Guralnik
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