High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study.

Arthritis Research & Therapy
Elke ArtsCalin D Popa

Abstract

Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect. Changed HDL composition through the impact of inflammation on HDL subfractions may contribute to the excess risk of CVD in rheumatoid arthritis (RA). In this study, we investigated whether HDL2-chol and HDL3-chol concentrations differ between RA patients and healthy controls, and whether these levels are related to the level of RA disease activity. Non-fasting blood samples were collected from 45 RA patients and 45 healthy controls. None of the participants had a history of CVD, diabetes, or used lipid-lowering drugs. HDL2-chol and HDL3-chol concentrations were obtained by ultracentrifugation. Regression modeling was used to compare HDL subfraction levels between RA patients and healthy controls, and to analyze the effect of disease activity on HDL2-chol and HDL3-chol. HDL2-chol and HDL3-chol were significantly lower in RA patients compared to healthy controls (P = 0.01, P = 0.005, respectively). The HDL2:HDL3 ratio was significantly lower in patients compared to controls (P = 0.04). Reduced HDL2-chol and...Continue Reading

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Citations

Jun 19, 2013·Nature Reviews. Rheumatology·Jamie RobertsonNaveed Sattar
Aug 31, 2014·Free Radical Biology & Medicine·Elizabeth J ReverriFrancene M Steinberg
Dec 17, 2014·Current Allergy and Asthma Reports·Ayse Bag-Ozbek, Jon T Giles
Mar 25, 2017·International Journal of Molecular Sciences·Patricia Reboredo-RodríguezGiuseppe Fregapane
Jan 7, 2017·Zeitschrift für Rheumatologie·D Aletaha, A Kerschbaumer
May 31, 2019·Current Opinion in Lipidology·Rachel H MackeyLarry W Moreland
Nov 24, 2016·Clinical Chemistry·Sotirios K KarathanasisAlan T Remaley
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diego Estrada-LunaGabriel Betanzos-Cabrera

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