High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture

Neuroreport
Z S FarhangraziD M Holtzman

Abstract

A hallmark of Alzheimer's disease (AD) is the extracellular deposition and accumulation of a 39-43 amino peptide, known as the amyloid beta (A beta) protein, within the brain. It has been postulated that A beta may in some way contribute directly to AD pathogenesis. The epsilon 4 allele of apolipoprotein E (apoE) is a major AD risk factor. Since both apoE and A beta are components of lipoproteins in plasma and cerebrospinal fluid, we asked whether lipoproteins and apoE isoforms would modify the toxicity of A beta (1-42) in cortical cell cultures. We show that high density lipoprotein with or without apoE reduces A beta toxicity and that apoE in the absence of lipoproteins does not affect A beta toxicity. These results suggest that interactions between A beta and lipoproteins in the brain could influence AD pathogenesis.

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Citations

Aug 11, 2000·Microscopy Research and Technique·G M Cole, M D Ard
Feb 14, 2009·Journal of Neural Transmission·Philipp GörtzChristian Lange-Asschenfeldt
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Nov 24, 2004·The Journal of Biological Chemistry·Radosveta P KoldamovaJohn S Lazo

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