PMID: 58949Apr 1, 1976

High density lipoprotein (HDL) polymorphisms in rabbit. II. A study of the inherited Hl 1 and R 67 antigens in relation to HDL polypeptides

Journal of Immunogenetics
A L Borresen

Abstract

Rabbit high density lipoprotein (HDL) has been isolated by ultracentrifugation delipidated by ether and ethanol, and treated with urea prior to separation of the different polypeptides by gel filtration. The two different genetic polymorphisms known in rabbit HDL were found to reside in two different polypeptides. This conclusion was reached in experiments where a quantitative radial immunodiffusion technique was employed. The results of polyacrylamide gel electrophoresis in SDS indicate that the Hl 1 antigen resides in a polypeptide chain with a molecular weight of 40,000. whereas the R 67 antigen resides in a chain with a molecular weight of 17,000.

Related Concepts

Antigenic Specificity
Electrophoresis, Agar Gel
SDS-PAGE
Immunodiffusion Measurement
Alpha-1 Lipoprotein
Genetic Polymorphism
Ultracentrifugation

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