High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection

Circulation
B J Van LentenA M Fogelman

Abstract

Viruses have been identified as one of a variety of potential agents that are implicated in atherogenesis. C57BL/6J mice were killed before or 2, 3, 5, 7, or 9 days after intranasal infection with 10(5) plaque-forming units (pfu) of Influenza A strain WSN/33. Peak infectivity in lungs was reached by 72 hours, and it returned to baseline by 9 days. No viremia was observed at any time. The activities of paraoxonase and platelet-activating factor acetylhydrolase in HDL decreased after infection and reached their lowest levels 7 days after inoculation. The ability of HDL from infected mice to inhibit LDL oxidation and LDL-induced monocyte chemotactic activity in human artery wall cell cocultures decreased with time after inoculation. Moreover, as the infection progressed, LDL more readily induced monocyte chemotaxis. Peak interleukin-6 and serum amyloid A plasma levels were observed at 2 and 7 days after inoculation. HDL apoA-I levels did not change. ApoJ and ceruloplasmin levels in HDL peaked 3 days after infection. Ceruloplasmin remained elevated throughout the time course, whereas apoJ levels decreased toward baseline after the third day. We conclude that alterations in the relative levels of paraoxonase, platelet-activating fac...Continue Reading

References

Sep 1, 1983·International Journal of Epidemiology·H E TillettC D Gooch
Apr 1, 1994·The Journal of Clinical Investigation·E EhrenwaldP L Fox
Jan 1, 1996·Trends in Microbiology·W J Britt
Nov 15, 1996·Biochimica Et Biophysica Acta·A Koj
Apr 15, 1997·The Journal of Clinical Investigation·M NavabB N La Du
Aug 1, 1997·Atherosclerosis·P R WoodhouseK T Khaw
Oct 10, 1998·Journal of Virology·A García-SastreJ E Durbin
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner

❮ Previous
Next ❯

Citations

Dec 16, 2006·Current Atherosclerosis Reports·Benjamin J AnsellAlan M Fogelman
Mar 1, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiuru GuanJin Zhou
Oct 28, 2009·Cardiovascular Drugs and Therapy·Mariann HarangiGyörgy Paragh
Jun 24, 2008·Inflammation·Xiu-Ru GuanHong-Yuan Li
Oct 8, 2013·Reviews in Endocrine & Metabolic Disorders·S ParkI K Lee
Aug 12, 2006·Current Atherosclerosis Reports·Benjamin J AnsellAlan M Fogelman
Apr 29, 2010·Current Atherosclerosis Reports·Kiyoko Uno, Stephen J Nicholls
Jan 16, 2004·Experimental Gerontology·Ildiko SeresAbdelouahed Khalil
Dec 17, 2003·Prostaglandins & Other Lipid Mediators·Mohamedain M Mahfouz, Fred A Kummerow
Oct 29, 2002·Trends in Immunology·David R Greaves, Keith M Channon
Sep 23, 2006·Nature Clinical Practice. Cardiovascular Medicine·Mohamad NavabAlan M Fogelman
Sep 8, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Mohamad NavabAlan M Fogelman
Mar 24, 2010·Nature Reviews. Nephrology·Nosratola D VaziriAlan M Fogelman
Oct 4, 2006·Cell Research·Belinda A CutriStephen J Nicholls
Oct 31, 2002·European Journal of Clinical Investigation·J J M BouwmanR J A Diepersloot
Sep 4, 2009·The Journal of Biological Chemistry·Arundhati UndurtiStanley L Hazen
Feb 19, 2008·Rejuvenation Research·Francesca MarchegianiClaudio Franceschi
Jul 3, 2013·Cardiovascular Research·Monica GomaraschiLaura Calabresi
Mar 17, 2011·European Heart Journal·Pradeep Natarajan, Christopher P Cannon
May 22, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D VaziriBernardo Rodriguez-Iturbe
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Isabella SudanoThomas F Lüscher
Aug 2, 2002·Current Opinion in Lipidology·Mohamad NavabSrinu T Ready
May 29, 2004·Current Opinion in Lipidology·Godfrey S Getz, Catherine A Reardon
Apr 17, 2010·Cardiology in Review·Courtney B ShermanWilliam H Frishman
Mar 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Hong Feng, Xiang-An Li
Jul 11, 2007·Current Opinion in Lipidology·Stephen J Nicholls, Steven E Nissen
Jul 11, 2007·Current Opinion in Lipidology·Benjamin J AnsellAlan M Fogelman
Sep 2, 2011·Current Opinion in Lipidology·Giuseppe D NorataAlberico L Catapano
Sep 1, 2006·Molecular and Cellular Biology·Nicolas VenteclefPhilippe Delerive
Nov 20, 2008·Cardiology·Mohammad MadjidWilliam A Blumentals
Aug 15, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan D Smith
Jul 25, 2012·Lipids in Health and Disease·Ayman Samir Farid, Yoichiro Horii
Nov 20, 2012·Journal of Lipid Research·Daniel S KimGail P Jarvik
Apr 4, 2008·Journal of Atherosclerosis and Thrombosis·Dmitri SviridovPaul Nestel
Jul 7, 2012·Southern Medical Journal·Kelly C RogersShannon W Finks
Jul 13, 2011·Journal of Endocrinological Investigation·L Tian, M Fu
Jun 28, 2014·TheScientificWorldJournal·Dileep Kumar, Syed Ibrahim Rizvi
Apr 16, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Talía SainzMaría A Muñoz-Fernández

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.