High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease

JACC. Basic to Translational Science
Nicholas J LeeperBryan Ronain Smith

Abstract

Nanoparticles promise to advance the field of cardiovascular theranostics. However, their sustained and targeted delivery remains an important obstacle. The body synthesizes some "natural" nanoparticles, including high-density lipoprotein (HDL), which may home to the atherosclerotic plaque and promote cholesterol efflux. In a recent article published in JACC: Cardiovascular Imaging, investigators generated modified, radiolabeled HDL nanoparticles and confirmed they accumulated in atherosclerotic lesions from several different species. These approaches hold promise for the noninvasive diagnosis of vulnerable plaque and in the stratification of patients in whom HDL-mimetic therapy may have a clinical benefit.

References

Apr 15, 2014·Nature Nanotechnology·Bryan Ronain SmithSanjiv Sam Gambhir
Jul 21, 2015·Current Opinion in Cardiology·Hasan K SiddiqiDaniel Rader
May 30, 2016·JACC. Cardiovascular Imaging·Carlos Pérez-MedinaWillem J M Mulder
Jun 6, 2016·Atherosclerosis·Kang He ZhengErik S G Stroes
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir

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Citations

Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irene Fernández-BarahonaFernando Herranz
Jan 27, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Jonathan VigneIsabelle Texier
Dec 28, 2017·Accounts of Chemical Research·Willem J M MulderCarlos Pérez-Medina

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Methods Mentioned

BETA
flow cytometry
X-ray

Clinical Trials Mentioned

NCT02820454

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