High-density lipoprotein restores endothelial function in hypercholesterolemic men

Circulation
Lukas E SpiekerGeorg Noll

Abstract

Hypercholesterolemia is a risk factor for atherosclerosis-causing endothelial dysfunction, an early event in the disease process. In contrast, high-density lipoprotein (HDL) cholesterol inversely correlates with morbidity and mortality representing a protective effect. Therefore, we investigated the effects of reconstituted HDL on endothelial function in hypercholesterolemic men. Endothelium-dependent and -independent vasodilation to intraarterial acetylcholine and sodium nitroprusside (SNP), respectively, was measured by forearm venous occlusion plethysmography in healthy normo- and hypercholesterolemic men. In hypercholesterolemics, the effects of reconstituted HDL (rHDL; 80 mg/kg IV over 4 hours) on acetylcholine- and SNP-induced changes in forearm blood flow were assessed in the presence or absence of the nitric oxide (NO) synthase inhibitor L-NMMA. Hypercholesterolemics showed reduced vasodilation to acetylcholine but not to SNP compared with normocholesterolemics (P<0.0001). rHDL infusion increased plasma HDL cholesterol from 1.3+/-0.1 to 2.2+/-0.1 mmol/L (P<0.0001, n=18) and significantly enhanced the acetylcholine-induced increase in forearm blood flow without affecting that induced by SNP. rHDL infusion also improved f...Continue Reading

Citations

Mar 5, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nada SallamIsmail Laher
Apr 7, 2009·European Journal of Applied Physiology·Michael HarrisonNiall M Moyna
Apr 13, 2010·Pflügers Archiv : European journal of physiology·Andreas J Flammer, Thomas F Lüscher
Dec 17, 2008·Current Atherosclerosis Reports·Jean-Claude TardifStephane Noble
Nov 9, 2010·Current Atherosclerosis Reports·Esad Vucic, Robert S Rosenson
Apr 6, 2011·Current Atherosclerosis Reports·Raphaël Duivenvoorden, Zahi A Fayad
Mar 24, 2007·Current Treatment Options in Cardiovascular Medicine·Prediman K Shah
Jun 13, 2003·Atherosclerosis·Philip BarterUNKNOWN Future Forum Editorial Board
Jun 25, 2003·International Journal of Cardiology·A H LiemD J van Veldhuisen
Jul 26, 2003·Diabetes Research and Clinical Practice·Marja Riitta Taskinen
Feb 8, 2003·Atherosclerosis. Supplements·Roger S Newton, Brian R Krause
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·M M ThompsonG W Cockerill
Feb 2, 2008·Nature Reviews. Drug Discovery·Tisha Joy, Robert A Hegele
Oct 4, 2006·Cell Research·Belinda A CutriStephen J Nicholls
Jan 5, 2006·International Journal of Impotence Research·J J RodriguezE R Schwarz
Sep 14, 2010·The Journal of Biological Chemistry·Ashley J WilhelmMary G Sorci-Thomas
Feb 24, 2009·Cardiovascular Research·Katherine Sattler, Bodo Levkau
Sep 17, 2011·European Heart Journal·Branko SimicFrank Ruschitzka
May 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thimoteus SpeerDanilo Fliser
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Isabella SudanoThomas F Lüscher
Feb 18, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Arnold von EckardsteinLucia Rohrer
Aug 18, 2005·Cardiology in Review·Tanaz Kermani, William H Frishman
Feb 24, 2006·Journal of Cardiovascular Pharmacology·Jeffrey T KuvinRichard H Karas
May 19, 2005·Pharmacogenetics and Genomics·Richard W JamesMarie-Claude Brulhart-Meynet
Jul 11, 2007·Current Opinion in Lipidology·Stephen J Nicholls, Steven E Nissen
May 4, 2011·Current Opinion in Lipidology·Jerzy-Roch Nofer, Miranda van Eck
Apr 21, 2012·Current Opinion in Lipidology·Bernd Hewing, Edward A Fisher
Sep 27, 2012·Current Opinion in Lipidology·Raphaël Duivenvoorden, Zahi A Fayad
Apr 9, 2010·Clinical and Experimental Pharmacology & Physiology·Karen L AndrewsJaye P F Chin-Dusting
Jul 25, 2012·Clinical and Experimental Pharmacology & Physiology·Enoch ChanShun-Wan Chan
Jun 18, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Richard M McAllisterM Harold Laughlin
Nov 5, 2002·Annual Review of Medicine·Gerd Assmann, Jerzy-Roch Nofer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.