High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.

Lipids in Health and Disease
Li TianMingde Fu

Abstract

A higher prevalence of coronary heart disease (CHD) in people with diabetes. We investigated the high-density lipoprotein (HDL) subclass profiles and alterations of particle size in CHD patients with diabetes or without diabetes. Plasma HDL subclasses were quantified in CHD by 1-dimensional gel electrophoresis coupled with immunodetection. Although the particle size of HDL tend to small, the mean levels of low density lipoprotein cholesterol(LDL-C) and total cholesterol (TC) have achieved normal or desirable for CHD patients with or without diabetes who administered statins therapy. Fasting plasma glucose (FPG), triglyceride (TG), TC, LDL-C concentrations, and HDL₃ (HDL(3b) and (3a)) contents along with Gensini Score were significantly higher; but those of HDL-C, HDL(2b+preβ2), and HDL(2a) were significantly lower in CHD patients with diabetes versus CHD patients without diabetes; The preβ₁-HDL contents did not differ significantly between these groups. Multivariate regression analysis revealed that Gensini Score was significantly and independently predicted by HDL(2a), and HDL(2b+preβ2). The abnormality of HDL subpopulations distribution and particle size may contribute to CHD risk in diabetes patients. The HDL subclasses dist...Continue Reading

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Citations

May 3, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rui-Xia XuJian-Jun Li
Apr 29, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ding RuWu Zonggui
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May 18, 2019·BMC Cardiovascular Disorders·Qiao ZhuYa-Li Zhao
Aug 28, 2021·Cells·Manuela CasulaAndrea Baragetti

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Methods Mentioned

BETA
electrophoresis
nuclear magnetic resonance

Software Mentioned

SPSS

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