High-density lipoproteins enhance progenitor-mediated endothelium repair in mice

Arteriosclerosis, Thrombosis, and Vascular Biology
Colin TsoPhilip J Barter

Abstract

We quantified endothelial progenitor cell (EPC) engraftment into the endothelial layer as an index of progenitor-mediated endothelial repair. Studies were conducted in C57BL/6J and in apolipoprotein E-deficient (apoE(-/-)) mice. We also investigated the possibility that high-density lipoproteins (HDL) may promote progenitor-mediated endothelial repair. Thoracic aortic sections from C57BL/6J and apoE(-/-) mice were analyzed for evidence of progenitor-derived endothelium as determined by the number of stem cell antigen-1-positive (Sca-1+) cells in the endothelial layer. EPCs (Sca-1+ cells) were significantly increased after endothelial damage induced by lipopolysaccharide (LPS) administration in C57BL/6J mice. The number of EPCs was greater in the aortic endothelium of untreated apoE(-/-) than in untreated C57BL/6J mice and was similar to the number observed in LPS-treated C57BL/6J mice. The number of EPCs in the aortic endothelium of apoE(-/-) mice more than doubled after intravenous infusion of reconstituted HDL. EPCs are recruited into the aortic endothelial layer of mice in response to an inflammatory insult. EPCs are also increased in the aortic endothelium of untreated apoE(-/-) mice. The observation that number is further ...Continue Reading

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M van de RijnI L Weissman
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T P QuinnL T Williams
Jan 5, 2000·The Journal of Clinical Investigation·Y LinR P Hebbel
May 8, 2002·The Journal of Cell Biology·Tetsuro TamakiV Reggie Edgerton
Mar 4, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Darrell N KottonAlan Fine
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mortaza BonyadiWilliam L Stanford
Jul 24, 2003·The American Journal of Pathology·Maarten B RookmaakerMarianne C Verhaar
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Toshio ImanishiIchiro Nishio
Dec 3, 2003·Blood·Daniel J PearceDominique Bonnet
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuhiro YamadaHidetada Sasaki
Nov 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Julie SainzAntoine Lafont

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Citations

Dec 11, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yingmei FengBart De Geest
Mar 5, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nada SallamIsmail Laher
Dec 17, 2008·Current Atherosclerosis Reports·Jean-Claude TardifStephane Noble
Nov 9, 2010·Current Atherosclerosis Reports·Esad Vucic, Robert S Rosenson
Nov 26, 2013·Heart, Lung & Circulation·Francesca CharltonAnnemarie Hennessy
Mar 25, 2009·Antioxidants & Redox Signaling·Masuko Ushio-Fukai, Norifumi Urao
Feb 24, 2009·Cardiovascular Research·Katherine Sattler, Bodo Levkau
Jun 26, 2009·European Heart Journal·Shirya RashidJacques Genest
May 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thimoteus SpeerDanilo Fliser
Apr 28, 2009·Current Opinion in Lipidology·Arnold von Eckardstein, Lucia Rohrer
Apr 9, 2010·Clinical and Experimental Pharmacology & Physiology·Karen L AndrewsJaye P F Chin-Dusting
Oct 2, 2012·Circulation Research·Chieko Mineo, Philip W Shaul
Jun 28, 2011·The Journal of Clinical Investigation·Christian BeslerUlf Landmesser
Jul 17, 2013·Cardiovascular Diabetology·Luis Masana
May 3, 2012·Journal of Lipid Research·Philip J Barter, Kerry-Anne Rye
Nov 27, 2008·Journal of Lipid Research·Kerry-Anne RyePhilip J Barter
Jan 5, 2014·PloS One·Kaemisa SrisenJosef Neumüller
May 3, 2013·Journal of Periodontology·Francesco D'AiutoJohn C Gunsolley
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Fuyong DuXiao-Feng Yang
May 4, 2011·World Journal of Biological Chemistry·Koichi Sato, Fumikazu Okajima
May 26, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Diana R ChirovskyPhilip Barter
Jul 13, 2011·Journal of Endocrinological Investigation·L Tian, M Fu
Sep 8, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Binxing LiPaul S Bernstein
Mar 30, 2007·Journal of Interventional Cardiology·Chunming Dong, Pascal J Goldschmidt-Clermont
Mar 18, 2016·Pharmacological Reviews·Philip J Barter, Kerry-Anne Rye
Jun 18, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sukhleen K MomiFrances M K Williams
Mar 12, 2015·Cardiovascular Research·Joanne T M TanChristina A Bursill
Feb 22, 2012·European Journal of Preventive Cardiology·Cátia B SeveroRicardo Stein
Apr 24, 2007·Journal of the American College of Cardiology·Javier SanzValentin Fuster
Dec 6, 2007·The American Journal of Cardiology·Prediman K Shah
May 12, 2007·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
Mar 13, 2014·Cardiology in Review·Lacey B Robinson, William H Frishman
Jul 3, 2013·Journal of Lipid Research·Kerry-Anne Rye, Philip J Barter
Jan 15, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Kyriakos E KypreosEsma R Isenovic
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Matteo PirroMassimo R Mannarino
Feb 7, 2017·World Journal of Cardiology·Kully SandhuRobert Butler
Jun 30, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Laura Z VanagsChristina A Bursill
Jan 24, 2018·Journal of the American Heart Association·Kwok Leung OngPhilip J Barter

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