High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia

British Journal of Haematology
David NgLynn R Goldin

Abstract

A subset of chronic lymphocytic leukaemia (CLL) shows familial aggregation. Studies show an increased risk for CLL and other lymphoproliferative disease among first-degree relatives of affected individuals. A genome-wide scan of 18 CLL families in 2003 detected LOD or non-parametric linkage scores > or = 1.0 on chromosomes 1, 3, 6, 12, 13 and 17. Follow-up study with 28 families showed no evidence of linkage at 1p22.1-p21.2, 3q22.1, 3q26.2, 6q22.31-q23.2, 12q24.23, 14q32.13, 17p13.3. Chromosome 13q21.33 remains a region of interest with a P-value of 0.013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL.

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Citations

Feb 5, 2011·Molecular Cytogenetics·Roger A SchultzMarilyn L Slovak
Apr 9, 2013·Hematology/oncology Clinics of North America·Ma Reina Improgo, Jennifer R Brown
Sep 8, 2010·Hematology/oncology Clinics of North America·Jane E Churpek, Kenan Onel
Aug 30, 2008·British Journal of Haematology·Jennifer R BrownArnold S Freedman
May 28, 2008·British Journal of Haematology·Stephen J FullerJames S Wiley

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