High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density

Bone
Sylvie GirouxFrançois Rousseau

Abstract

Osteoporosis is a bone disease characterized by low bone mineral density (BMD), a highly heritable and polygenic trait. Women are more prone than men to develop osteoporosis due to a lower peak bone mass and accelerated bone loss at menopause. Peak bone mass has been convincingly shown to be due to genetic factors with heritability up to 80%. Menopausal bone loss has been shown to have around 38% to 49% heritability depending on the site studied. To have more statistical power to detect small genetic effects we focused on premenopausal women. We studied 23 candidate genes, some involved in calcium and vitamin-D regulation and others because estrogens strongly induced their gene expression in mice where it was correlated with humerus trabecular bone density. High-density polymorphisms were selected to cover the entire gene variability and 231 polymorphisms were genotyped in a first sample of 709 premenopausal women. Positive associations were retested in a second, independent, sample of 673 premenopausal women. Ten polymorphisms remained associated with BMD in the combined samples and one was further associated in a large sample of postmenopausal women (1401 women). This associated polymorphism was located in the gene CSF3R (gra...Continue Reading

References

Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N TakahashiT Suda
Sep 1, 1987·The Journal of Clinical Investigation·N A PocockS Eberl
Nov 1, 1973·The Journal of Clinical Investigation·D M SmithC C Johnston
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A RubinD E Cole
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A JamalG A Hawker
Apr 27, 2000·Clinical Genetics·Y Giguère, F Rousseau
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marie K LindbergClaes Ohlsson
Apr 11, 2003·Reviews of Physiology, Biochemistry and Pharmacology·G J M van de GeijnI P Touw
May 13, 2003·The Journal of Endocrinology·Yao-Zhong LiuHong-Wen Deng
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Audrey KoayMatthew A Brown
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hui ShenHong-Wen Deng
Jul 6, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Lillian B BrownBraxton D Mitchell
Aug 3, 2005·PLoS Medicine·John P A Ioannidis
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joyce B J van MeursAndré G Uitterlinden
Oct 25, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fiona E A McGuiganStuart H Ralston
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Alister C Ward
Sep 22, 2007·Calcified Tissue International·Carles Vilariño-GüellMatthew A Brown
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Joyce B J van MeursUNKNOWN GENOMOS Study
Apr 18, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S GirouxF Rousseau
May 1, 2008·The New England Journal of Medicine·Unnur StyrkarsdottirKari Stefansson
Jun 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Claudie BergerUNKNOWN Canadian Multicentre Osteoporosis Study Research Group
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keisuke HoriuchiYoshiaki Toyama
Oct 6, 2009·Nature Genetics·Fernando RivadeneiraUNKNOWN Genetic Factors for Osteoporosis (GEFOS) Consortium
Oct 21, 2009·Annals of Internal Medicine·J Brent RichardsUNKNOWN Genetic Factors for Osteoporosis Consortium

❮ Previous
Next ❯

Citations

May 13, 2014·BoneKEy Reports·Peter R Ebeling
Jul 22, 2015·Rheumatology International·Shahryar Noordin, Julie Glowacki
Nov 16, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jibin ShaZhaoqing Wang
Jan 30, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·Katia Franco MouraManoel João Girão

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.