High-Density Stretchable Electrode Grids for Chronic Neural Recording

Advanced Materials
Klas TybrandtJános Vörös

Abstract

Electrical interfacing with neural tissue is key to advancing diagnosis and therapies for neurological disorders, as well as providing detailed information about neural signals. A challenge for creating long-term stable interfaces between electronics and neural tissue is the huge mechanical mismatch between the systems. So far, materials and fabrication processes have restricted the development of soft electrode grids able to combine high performance, long-term stability, and high electrode density, aspects all essential for neural interfacing. Here, this challenge is addressed by developing a soft, high-density, stretchable electrode grid based on an inert, high-performance composite material comprising gold-coated titanium dioxide nanowires embedded in a silicone matrix. The developed grid can resolve high spatiotemporal neural signals from the surface of the cortex in freely moving rats with stable neural recording quality and preserved electrode signal coherence during 3 months of implantation. Due to its flexible and stretchable nature, it is possible to minimize the size of the craniotomy required for placement, further reducing the level of invasiveness. The material and device technology presented herein have potential ...Continue Reading

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Citations

Oct 17, 2018·Journal of Neural Engineering·Aline F RenzJanos Vörös
Jan 9, 2019·Advanced Materials·Magnus BerggrenIgor Zozoulenko
Feb 26, 2019·Advanced Materials·Kezhong WangGordon Wallace
May 11, 2019·Chemical Society Reviews·Naoji MatsuhisaTakao Someya
Jun 18, 2019·Advanced Materials·Nikita ObidinCanan Dagdeviren
Aug 14, 2019·Advanced Materials·Dong Chan KimDae-Hyeong Kim
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Oct 15, 2019·Advanced Materials·Florian FalleggerStéphanie P Lacour
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Sep 18, 2020·Advanced Healthcare Materials·Ruihua DongXingyu Jiang
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May 7, 2021·Journal of Neural Engineering·Samuel LienemannKlas Tybrandt
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May 30, 2021·Advanced Healthcare Materials·Mengjia ZhuYingying Zhang

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