High diagnostic value in rheumatoid arthritis of antibodies to the stratum corneum of rat oesophagus epithelium, so-called 'antikeratin antibodies'.

Annals of the Rheumatic Diseases
C VincentJ P Soleilhavoup

Abstract

Serum antibodies to the stratum corneum of rat oesophagus epithelium, so-called 'antikeratin antibodies', have been largely demonstrated in rheumatoid arthritis (RA). IgM and IgG antibodies to this epithelium were studied by semiquantitative immunofluorescence in 528 patients with perfectly characterised rheumatic diseases, including 178 with classical or definite RA. Histological analysis of IgG antibodies showed that only antibodies which produce a linear laminated pattern restricted to the stratum corneum (IgG antikeratin antibodies) are highly specific for RA; all the other labelling patterns are not disease specific. By a semiquantitative evaluation of the stratum corneum fluorescence intensity it was shown that the diagnostic value of IgG antikeratin antibodies closely depends on their titre and it was established in objective conditions that the sensitivity is 43.26% when the specificity reaches 99.14%. A high titre of IgG antikeratin antibodies was actually pathognomonic for RA. Both the histological and semi-quantitative analyses showed that IgM antibodies to rat oesophagus epithelium, though frequently detected, are of no diagnostic value, either for RA or for any other rheumatic disease that was studied. From a revie...Continue Reading

References

Jul 14, 1979·British Medical Journal·B J YoungT J Hamblin
Jan 1, 1987·Scandinavian Journal of Rheumatology·H Kirstein, F K Mathiesen
Aug 1, 1985·Arthritis and Rheumatism·J L SenécalN Rothfield
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1981·Annals of the Rheumatic Diseases·G D JohnsonG Russell
Jun 1, 1981·Annals of the Rheumatic Diseases·D L ScottK W Walton
Sep 1, 1982·Clinical Rheumatology·P MiossecM P Moineau
Feb 1, 1982·Annals of the Rheumatic Diseases·O A OsungE J Holborow
Jul 1, 1964·Annals of the Rheumatic Diseases·R L NIENHUIS, E MANDEMA

❮ Previous
Next ❯

Citations

Nov 8, 2003·Trends in Molecular Medicine·Ryo YamadaKazuhiko Yamamoto
Sep 26, 1997·Journal of Dermatological Science·M ManabeH Ogawa
Jan 26, 2012·Mucosal Immunology·D FarquharsonS Culshaw
May 1, 2002·Current Opinion in Rheumatology·ZhiJie Zhou, Henri-André Ménard
Sep 14, 2004·Annals of the Rheumatic Diseases·D AletahaJ S Smolen
Jun 1, 1992·Annals of the Rheumatic Diseases·L PaimelaM Leirisalo-Repo
Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková
May 31, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ling LinZe Yang
Feb 14, 1998·The Journal of Clinical Investigation·G A SchellekensW J van Venrooij
Apr 6, 2006·The Journal of Clinical Investigation·Kristine A KuhnV Michael Holers
Jan 5, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Koichiro Ohmura
May 2, 2014·Mediators of Inflammation·Agata N BurskaFrederique Ponchel
Jun 1, 1994·Seminars in Arthritis and Rheumatism·K AhoP Kurki
Feb 1, 1992·Baillière's Clinical Rheumatology·F A Wollheim, K B Eberhardt
Nov 1, 2006·Arthritis and Rheumatism·Tineke CantaertDominique Baeten
Jul 15, 2005·Annals of the New York Academy of Sciences·I AbreuJ A Machado Caetano
Oct 2, 2001·Scandinavian Journal of Rheumatology·K ForslindB Svensson
Sep 26, 2007·Annals of the New York Academy of Sciences·Akari SuzukiKazuhiko Yamamoto
Nov 28, 2000·Scandinavian Journal of Rheumatology·K ForslindB Svensson
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Masson-BessièreG Serre
Apr 5, 2005·Autoimmunity·Christian VincentGuy Serre
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Floris van GaalenRené E M Toes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.