High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function

Scientific Reports
V B SilvaR M Elias

Abstract

Dialysate calcium concentration (d[Ca]) might have a cardiovascular impact in patients on haemodialysis (HD) since a higher d[Ca] determines better hemodynamic tolerability. We have assessed the influence of d[Ca] on global longitudinal strain (GLS) by two-dimensional echocardiography using speckle-tracking imaging before and in the last hour of HD. This is an observational crossover study using d[Ca] 1.75 mmol/L and 1.25 mmol/L. Ultrafiltration was the same between interventions; patients aged 44 ± 13 years (N = 19). The 1.75 mmol/L d[Ca] was associated with lighter drop of blood pressure. Post HD serum total calcium was higher with d[Ca] 1.75 than with 1.25 mmol/L (11.5 ± 0.8 vs. 9.1 ± 0.5 mg/dL, respectively, p < 0.01). In almost all segments strain values were significantly worse in the peak HD with 1.75 mmol/L d[Ca] than with 1.25 mmol/L d[Ca]. GLS decreased from -19.8 ± 3.7% at baseline to -17.3 ± 2.9% and -16.1 ± 2.6% with 1.25 d[Ca] and 1.75 d[Ca] mmol/L, respectively (p < 0.05 for both d[Ca] vs. baseline and 1.25 d[Ca] vs. 1.75 d[Ca] mmol/L). Factors associated with a worse GLS included transferrin, C-reactive protein, weight lost, and post dialysis serum total calcium. We concluded that d[Ca] of 1.75 mmol/L was associ...Continue Reading

References

Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·V K VirtanenA I Pasternack
Feb 23, 1999·Kidney International·S E NäppiA I Pasternack
Jan 12, 2002·Kidney International·John KyriazisIrene Grimani
Mar 13, 2003·Kidney International·Kamyar Kalantar-ZadehJoel D Kopple
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliLorenzo S Malatino
Apr 6, 2007·Nephron. Clinical Practice·John KyriazisEugene Daphnis
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Nicholas M SelbyChristopher W McIntyre
Jun 3, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James O BurtonChristopher W McIntyre
Feb 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cristina KarohlRosa Maria Affonso Moysés
Sep 3, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Aude MignotStéphane Lafitte
Sep 11, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Francis VerbekeUNKNOWN CORD Study Investigators
Dec 24, 2010·American Journal of Nephrology·Yen-Wen LiuWei-Chuan Tsai
May 21, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Helen J JefferiesChristopher W McIntyre
Aug 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Melani R CustódioVanda Jorgetti
Sep 24, 2011·Journal of the American College of Cardiology·John Gorcsan, Hidekazu Tanaka
Jul 24, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Tobias BreidthardtChristopher W McIntyre
Aug 2, 2012·Cardiorenal Medicine·Mozow Y Zuidema, Kevin C Dellsperger
Oct 2, 2012·Néphrologie & thérapeutique·Guillaume JeanUNKNOWN investigateurs de l’étude ARNOS
Feb 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Patrick H PunJohn P Middleton
May 1, 2013·Seminars in Dialysis·Dvora RubingerDan Sapoznikov
May 25, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Yen-Wen LiuWei-Chuan Tsai
Dec 23, 2014·Kidney & Blood Pressure Research·Bruno C SilvaRosilene M Elias
Nov 14, 2015·Hemodialysis International·Patrick H PunJohn P Middleton
Oct 16, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pantelis A SarafidisHaralambos Karvounis
Dec 16, 2016·Kidney & Blood Pressure Research·Zaida N C JimenezRosilene M Elias
Jan 27, 2017·Journal of the American Society of Nephrology : JASN·Charlotte BuchananChris W McIntyre

❮ Previous
Next ❯

Citations

Oct 28, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Rosilene M EliasRosa M A Moysés

❮ Previous
Next ❯

Methods Mentioned

BETA
SGA

Clinical Trials Mentioned

NCT02545426

Software Mentioned

EchoPAC
GraphPad Prism®
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.