High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model

Aging Cell
Irit LubitzMichal Schnaider-Beeri

Abstract

There is growing evidence of the involvement of advanced glycation end products (AGEs) in the pathogenesis of neurodegenerative processes including Alzheimer's disease (AD) and their function as a seed for the aggregation of Aβ, a hallmark feature of AD. AGEs are formed endogenously and exogenously during heating and irradiation of foods. We here examined the effect of a diet high in AGEs in the context of an irradiated diet on memory, insoluble Aβ42 , AGEs levels in hippocampus, on expression of the receptor for AGEs (RAGE), and on oxidative stress in the vasculature. We found that AD-like model mice on high-AGE diet due to irradiation had significantly poorer memory, higher hippocampal levels of insoluble Aβ42 and AGEs as well as higher levels of oxidative stress on vascular walls, compared to littermates fed an isocaloric diet. These differences were not due to weight gain. The data were further supported by the overexpression of RAGE, which binds to Aβ42 and regulates its transport across the blood-brain barrier, suggesting a mediating pathway. Because exposure to AGEs can be diminished, these insights provide an important simple noninvasive potential therapeutic strategy for alleviating a major lifestyle-linked disease epi...Continue Reading

Associated Clinical Trials

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Citations

Nov 11, 2016·Journal of Tropical Medicine·Mohammad Taghi GoodarziEbrahim Abbasi Oshaghi
Mar 23, 2018·Journal of Medicinal Food·Alice Barros CâmaraRodrigo Juliani Siqueira Dalmolin
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Joanna WojsiatUrszula Wojda
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Nov 23, 2019·International Journal of Molecular Sciences·Rita Moretti, Costanza Peinkhofer
May 13, 2019·Molecular and Cellular Biochemistry·Kailash Prasad
May 13, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michal Schnaider BeeriVahram Haroutunian
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Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Tauqeerunnisa Syeda, Jason R Cannon
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Mar 27, 2021·Annual Review of Food Science and Technology·Yan ZhangShuo Wang

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Methods Mentioned

BETA
dot blot
PCR
Protein Assay
ELISA

Software Mentioned

imagej
Cellsens Entry
NIH Image
SPSS
hvs image field

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