High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves

Journal of Dairy Science
S L HansenJ W Spears

Abstract

A 56-d experiment was designed to examine the effect of high dietary Fe on metal transporters involved in Fe and Mn metabolism. Fourteen weaned Holstein calves were stratified by weight and randomly assigned to 1 of 2 treatments: 1) no supplemental Fe (normal Fe) or 2) 750mg of supplemental Fe/kg of dry matter (high Fe). Jugular blood was collected on d 0, 35, and 56. At the end of the trial, 6 calves per treatment were humanely killed and duodenal scrapings, liver, and heart were collected for analysis. Additionally, proximal duodenum was mounted on Ussing chambers to assess intestinal barrier integrity. Calves receiving high dietary Fe displayed decreased transepithelial resistance and increased apical-to-basolateral flux of radiolabeled mannitol, suggesting that high Fe created increased intestinal permeability. Feeding calves a diet high in Fe decreased average daily gain, dry matter intake, and feed efficiency. Hemoglobin and serum Fe concentrations did not differ due to dietary treatment. High dietary Fe increased concentrations of Fe in the liver, but did not affect heart or duodenal Fe concentrations. Duodenal Mn concentrations were lowered by feeding a high Fe diet, but liver and heart Mn concentrations were not affect...Continue Reading

References

May 1, 1970·Journal of Dairy Science·T HamadaK Kameoka
Jul 1, 1997·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A C Chua, E H Morgan
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·N C Andrews
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M E ConradM D Garrick
Sep 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nadia Hubert, Matthias W Hentze
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Michael D GarrickLaura M Garrick
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mitchell D KnutsonMarianne Wessling-Resnick
Dec 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marianne Wessling-Resnick
Jun 23, 2006·Biochimica Et Biophysica Acta·Tomas Ganz, Elizabeta Nemeth
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam J MoeserAnthony T Blikslager
Sep 9, 2008·The British Journal of Nutrition·Stephanie L HansenJerry W Spears
May 19, 2009·Journal of Dairy Science·S L Hansen, J W Spears

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Citations

Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Carolyn N GrimesMichael M Fry
Apr 12, 2016·Journal of Dairy Science·Aili WangAndrea M Dietrich
Sep 11, 2014·FEMS Microbiology Reviews·Guus A M KortmanHarold Tjalsma
May 29, 2012·The Veterinary Journal·Peter J White, Peter A Windsor
Sep 27, 2018·Journal of Animal Science·Lin LuXugang Luo
Feb 10, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Supak JenkitkasemwongMitchell D Knutson
Jun 9, 2019·Biological Trace Element Research·S A MiroshnikovA R Grabeklis
Jul 15, 2017·International Journal of Molecular Sciences·Robert KupczyńskiKrystyna Pogoda-Sewerniak
Mar 18, 2020·Archives of Toxicology·Geir BjørklundJan Aaseth
Dec 11, 2019·Animals : an Open Access Journal From MDPI·Nageshvar PatelGiovanni Bittante
Jun 24, 2019·Biological Trace Element Research·Shiping BaiZuowei Su
Sep 28, 2018·Biological Trace Element Research·Jerry W Spears

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