High dietary zinc supplementation increases the occurrence of tetracycline and sulfonamide resistance genes in the intestine of weaned pigs

Gut Pathogens
W VahjenJ Zentek

Abstract

Dietary zinc oxide is used in pig nutrition to combat post weaning diarrhoea. Recent data suggests that high doses (2.5 g/kg feed) increase the bacterial antibiotic resistance development in weaned pigs. Therefore, the aim of this study was to investigate the development of enterobacterial antibiotic resistance genes in the intestinal tract of weaned pigs. Weaned pigs were fed diets for 4 weeks containing 57 (low), 164 (intermediate) or 2425 (high) mg kg(-1) analytical grade ZnO. DNA extracts from stomach, mid-jejunum, terminal ileum and colon ascendens were amplified by qPCR assays to quantify copy numbers for the tetracycline (tetA) and sulfonamide (sul1) resistance genes in Gram-negative bacteria. Overall, the combined data (n = 336) showed that copy numbers for tetracycline and sulfonamide resistance genes were significantly increased in the high zinc treatment compared to the low (tetA: p value < 10(-6); sul1: p value = 1 × 10(-5)) or intermediate (tetA: P < 1.6 × 10(-4); sul1: P = 3.2 × 10(-4)) zinc treatment. Regarding the time dependent development, no treatment effects were seen 1 week after weaning, but significant differences between high and low/intermediate zinc treatments evolved 2 weeks after weaning. The increas...Continue Reading

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Citations

May 18, 2017·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ilka Ute Emmerich
Jun 24, 2017·Animal Health Research Reviews·Eva-Maria SaliuJürgen Zentek
May 21, 2017·Acta Veterinaria Scandinavica·Mohamed RhoumaAnn Letellier
Feb 6, 2020·Scientific Reports·Jolinda PollockAlexander Corbishley
Jan 24, 2017·EFSA Journal·UNKNOWN EMA Committee for Medicinal Products for Veterinary Use (CVMP) and EFSA Panel on Biological Hazards (BIOHAZ)Helen Jukes
Aug 1, 2018·Veterinary Research·Yousef I HassanChengbo Yang
Aug 11, 2017·Porcine Health Management·Andrea Luppi
May 24, 2017·Journal of Public Health Policy·Jorge Pinto Ferreira, Katharina Staerk
Apr 28, 2018·Animal Frontiers : the Review Magazine of Animal Agriculture·Benjamin P WillingBenjamin C T Bourrie
Apr 14, 2020·Australian Veterinary Journal·R CutlerUNKNOWN Australian Veterinary Association Ltd and Animal Medicines Australia
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Robert Davies, Andrew Wales
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Andrea BonettiEster Grilli
Jun 20, 2018·Microbiology Spectrum·David H Lloyd, Stephen W Page

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