High Disease Activity Is Associated with Self-reported Depression and Predicts Persistent Depression in Early Rheumatoid Arthritis: Results from the Ontario Best Practices Research Initiative

The Journal of Rheumatology
B KuriyaOntario Best Practices Research Initiative Investigators

Abstract

We sought to determine if initial high disease activity or changes in disease activity contribute to persistent depression in early rheumatoid arthritis (ERA). We also determined if disease activity and depression is modified by sex. Depression was ascertained by self-report among patients enrolled in the Ontario Best Practices Research Initiative. The association between baseline disease activity, measured by the Clinical Disease Activity Index (CDAI), and persistent depression was evaluated with multivariate regression models, and effect modification by sex was tested. A general estimating equation assessed the association between change in CDAI over time and risk of depression. The sample of 469 ERA subjects was predominantly female (73%). At baseline, the prevalence of depression was 26%, and 23% reported persistent depression. After adjusting for potential confounders, higher baseline CDAI was associated with both baseline and persistent depression (OR 1.03, 95% CI 1.01-1.05). Female sex was an effect modifier of this relationship (OR 1.04, 95% CI 1.01-1.06). Maintaining a moderate or high CDAI score over 2 years also increased the risk of future depression. Depression in ERA is common and initial high disease activity is ...Continue Reading

References

Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jan 15, 2014·Nature Reviews. Rheumatology·Helga RadnerDaniel H Solomon
Mar 23, 2017·Rheumatology and Therapy·Louis JacobKarel Kostev

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Citations

Feb 23, 2019·Current Opinion in Rheumatology·Isabelle A VallerandCheryl Barnabe
Jun 20, 2020·Therapeutic Advances in Musculoskeletal Disease·Bindee KuriyaNigil Haroon
Dec 29, 2020·Frontiers in Medicine·Francesca IngegnoliRoberto Caporali

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