High diversity of Cryptosporidium subgenotypes identified in Malaysian HIV/AIDS individuals targeting gp60 gene.

PloS One
Asma IqbalBenedict L H Sim

Abstract

Currently, there is a lack of vital information in the genetic makeup of Cryptosporidium especially in developing countries. The present study aimed at determining the genotypes and subgenotypes of Cryptosporidium in hospitalized Malaysian human immunodeficiency virus (HIV) positive patients. In this study, 346 faecal samples collected from Malaysian HIV positive patients were genetically analysed via PCR targeting the 60 kDa glycoprotein (gp60) gene. Eighteen (5.2% of 346) isolates were determined as Cryptosporidium positive with 72.2% (of 18) identified as Cryptosporidium parvum whilst 27.7% as Cryptosporidium hominis. Further gp60 analysis revealed C. parvum belonging to subgenotypes IIaA13G1R1 (2 isolates), IIaA13G2R1 (2 isolates), IIaA14G2R1 (3 isolates), IIaA15G2R1 (5 isolates) and IIdA15G1R1 (1 isolate). C. hominis was represented by subgenotypes IaA14R1 (2 isolates), IaA18R1 (1 isolate) and IbA10G2R2 (2 isolates). These findings highlighted the presence of high diversity of Cryptosporidium subgenotypes among Malaysian HIV infected individuals. The predominance of the C. parvum subgenotypes signified the possibility of zoonotic as well as anthroponotic transmissions of cryptosporidiosis in HIV infected individuals.

References

Jul 1, 1991·Clinical Microbiology Reviews·W L Current, L S Garcia
Jun 1, 1994·The Journal of Applied Bacteriology·A T CampbellR W Girdwood
Feb 12, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·T R NavinR T Bryan
Mar 22, 2002·The Journal of Eukaryotic Microbiology·I M SulaimanL Xiao
Mar 22, 2002·The Journal of Eukaryotic Microbiology·M M PengL Xiao
May 25, 2002·Emerging Infectious Diseases·Scott GlabermanLihua Xiao
Mar 29, 2003·Journal of Molecular Evolution·Marianne MallonAndy Tait
Apr 5, 2003·Wiener klinische Wochenschrift·Mirjana Stantic-PavlinicIngrid Berce
Apr 5, 2003·Journal of Applied Microbiology·P R Hunter
Jan 23, 2004·The Journal of Eukaryotic Microbiology·Margarida AlvesFrancisco Antunes
Jan 23, 2004·The Journal of Eukaryotic Microbiology·Michael M PengLihua Xiao
Sep 9, 2004·Current Opinion in Infectious Diseases·Lihua Xiao, Una M Ryan
Mar 22, 2005·International Journal for Parasitology·Rachel M ChalmersMelita Stevens
Jun 1, 2005·The Veterinary Record·H V SmithJ M Wastling
Jun 16, 2005·Journal of Clinical Microbiology·Irshad M SulaimanLihua Xiao
Dec 1, 1993·Applied and Environmental Microbiology·A T CampbellH V Smith
Sep 29, 2006·Journal of Clinical Microbiology·Dawn C FeltusJohn M McEvoy
Oct 3, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wangeci GateiLihua Xiao
Oct 7, 2006·Parasitology Research·Lihua XiaoRonald Fayer
Oct 13, 2006·Parasitology Research·Heather P ThompsonLihua Xiao
Feb 7, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Ching HungKua-Eyre Su
Mar 30, 2007·Veterinary Parasitology·Judit Plutzer, Panagiotis Karanis
Aug 4, 2007·The Journal of Infectious Diseases·Vitaliano A CamaLihua Xiao
Aug 28, 2007·Applied and Environmental Microbiology·Yaoyu FengLihua Xiao
Dec 7, 2007·International Journal for Parasitology·Peter R WielingaJoke W B van der Giessen
Dec 18, 2007·The Veterinary Journal·Emily J BrookRobert M Christley
Jan 23, 2008·Journal of Water and Health·Y A L LimH V Smith
Jul 16, 2008·Applied and Environmental Microbiology·Joaquín QuílezCaridad Sánchez-Acedo
Oct 2, 2008·Emerging Infectious Diseases·Vitaliano A CamaLihua Xiao
Nov 18, 2008·Molecular and Cellular Probes·Aradhana PangasaRobin B Gasser
Mar 24, 2009·Experimental Parasitology·Ronald Fayer
Sep 22, 2009·BMC Infectious Diseases·Shimelis AssefaTechalew Shimelis

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Citations

Apr 24, 2014·PloS One·Olivia ValenzuelaLihua Xiao
Apr 8, 2014·Experimental Parasitology·M KoinariU M Ryan
Feb 2, 2013·Parasitology·N A AlyousefiR Mahmud
Aug 22, 2012·Current Opinion in Infectious Diseases·Debbie-Ann T ShirleyKaren L Kotloff
May 7, 2013·Veterinary Parasitology·Ignacio García-PresedoJosé Antonio Castro-Hermida
Mar 23, 2017·Marine Pollution Bulletin·Edison Jay A Pagoso, Windell L Rivera
Feb 8, 2018·Parasitology Research·Jorge Néstor VelásquezSilvana Carnevale
May 13, 2017·Parasite : Journal De La Société Française De Parasitologie·Djahida BenhoudaSimone M Cacciò
Nov 8, 2018·Parasites & Vectors·Djamel BaroudiLihua Xiao
Jul 28, 2019·PLoS Neglected Tropical Diseases·M Jahangir HossainMyron M Levine
Nov 4, 2020·Parasite : Journal De La Société Française De Parasitologie·Léa BordesRomy Razakandrainibe
Feb 26, 2021·Clinical Microbiology Reviews·Xin YangYaoyu Feng
May 1, 2020·Parasite : Journal De La Société Française De Parasitologie·Ehsan AhmadpourHossein Bannazadeh Baghi
Apr 28, 2019·Veterinary Parasitology : Regional Studies and Reports·Lynda SahraouiKarim Tarik Adjou
Jun 12, 2021·PloS One·Ambachew W HailuBeyene Petros

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Datasets Mentioned

BETA
HQ631411
HQ631423
HQ631406
HQ631410
HQ631409
HQ631408

Methods Mentioned

BETA
PCR

Software Mentioned

BioEdit
Biosystems Sequence Scanner
Clustal W
BLAST
Treeview X
MrBayes
Applied

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