High diversity of group A streptococcal emm types among healthy schoolchildren in Ethiopia

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Alemseged AbdissaAbraham Aseffa

Abstract

Although the prevalence of rheumatic heart disease in Ethiopia is one of the highest in the world, the epidemiology of group A streptococci (GAS) in this country is little known. GAS typing is a hallmark of both the epidemiology and understanding of diseases caused by these organisms. We have therefore conducted this study to investigate the emm (M-protein gene) type distribution of GAS carriers among Ethiopian schoolchildren. In the present study, we performed emm typing of 82 GAS isolates collected from the throats of healthy schoolchildren (6-14 years of age) residing in 3 different urban sites in Ethiopia: Addis Ababa, Gondar, and Dire Dawa. We report high diversity of GAS isolates recovered from healthy schoolchildren. Eighty-two isolates represented 43 different sequence types. Thirteen newly described subtypes were detected in this study. Of the emm types prevalent in the study communities, 46% were not included in the 26-valent GAS vaccine. The high diversity of emm types encountered within 3 months of collection suggest that production of a vaccine candidate based on the M-protein amino termini appears to be impractical for this population. We suggest that investigations of other vaccine candidates, including the C5a p...Continue Reading

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Citations

Dec 22, 2006·PloS One·Pierre Robert SmeestersLaurence Van Melderen
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronit Cohen-Poradosu, Dennis L Kasper
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rosalyn E O'LoughlinUNKNOWN Active Bacterial Core Surveillance Team
Jun 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Noémie BarouxPierre R Smeesters
Jan 27, 2016·Emerging Infectious Diseases·Anna C SealeJames A Berkley
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hassan M Al-EmranAbdramane Bassiahi Soura
Jan 9, 2016·Journal of Tropical Pediatrics·Smriti ChauhanLata Chandel
Mar 20, 2008·Journal of Medical Microbiology·Thangam MenonBernard Beall
Nov 21, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Milena Soares SantosJoice Neves Reis
Apr 4, 2014·Clinical Microbiology Reviews·Mark J WalkerVictor Nizet
Nov 13, 2009·Expert Review of Vaccines·Pierre R SmeestersMelina M Georgousakis
Nov 5, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Magnus G JespersenMark R Davies

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