High-dosage continuous amiodarone therapy to treat new-onset supraventricular tachyarrhythmias in surgical intensive care patients: an observational study

Wiener klinische Wochenschrift
Andreas J MayrWalter Hasibeder

Abstract

New-onset supraventricular tachyarrhythmias (SVTA) are a complication contributing significantly to morbidity and mortality in surgical intensive care unit (SICU) patients. Although only few data on efficiency can be found in the literature, class III antiarrhythmics have become popular in the treatment of SVTA in critically ill patients. 12-bed general and surgical ICU in a university teaching hospital. Observational, retrospective study. 131 SICU patients with SVTA (narrow-complex non-sinus tachyarrhythmias with heart rates > or = 100 bpm). High-dosage amiodarone infusion according to an institutional protocol. Hemodynamic data, acid-base status, and single organ functions were obtained in all patients before amiodarone infusion and at 12, 24, and 48 hours afterwards. Patients were divided into responders and nonresponders. Amiodarone infusion (mean dosage 24 h: 1625+/-528 mg; 48 h: 2708+/-895 mg) restored sinus rhythm in 54% of study patients within 12 h, in 64% within 24 h, and in 75% within 48 h. Heart rate, central venous pressure, and milrinone requirements significantly decreased in all patients; this was accompanied by a significant increase in stroke-volume index and mean arterial pressure. Serum concentrations of cre...Continue Reading

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Citations

Nov 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Mengalvio E SleeswijkJan G Zijlstra
Jun 13, 2008·Biopharmaceutics & Drug Disposition·Leos FuksaStanislav Micuda
Aug 26, 2009·Journal of Intensive Care Medicine·Martin W Dünser, Walter R Hasibeder
Jul 23, 2021·Critical Care : the Official Journal of the Critical Care Forum·Laura DrikiteMark Corbett

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