Abstract
New-onset supraventricular tachyarrhythmias (SVTA) are a complication contributing significantly to morbidity and mortality in surgical intensive care unit (SICU) patients. Although only few data on efficiency can be found in the literature, class III antiarrhythmics have become popular in the treatment of SVTA in critically ill patients. 12-bed general and surgical ICU in a university teaching hospital. Observational, retrospective study. 131 SICU patients with SVTA (narrow-complex non-sinus tachyarrhythmias with heart rates > or = 100 bpm). High-dosage amiodarone infusion according to an institutional protocol. Hemodynamic data, acid-base status, and single organ functions were obtained in all patients before amiodarone infusion and at 12, 24, and 48 hours afterwards. Patients were divided into responders and nonresponders. Amiodarone infusion (mean dosage 24 h: 1625+/-528 mg; 48 h: 2708+/-895 mg) restored sinus rhythm in 54% of study patients within 12 h, in 64% within 24 h, and in 75% within 48 h. Heart rate, central venous pressure, and milrinone requirements significantly decreased in all patients; this was accompanied by a significant increase in stroke-volume index and mean arterial pressure. Serum concentrations of cre...Continue Reading
References
Jan 1, 1992·Drugs·J GillA Fitton
Apr 1, 1992·International Journal of Cardiology·G Vietti-RamusR Latini
Dec 1, 1990·Critical Care Medicine·H Artucio, M Pereira
Sep 1, 1986·Journal of Cardiovascular Pharmacology·N VenkateshB N Singh
Feb 19, 1987·The New England Journal of Medicine·J W Mason
Oct 1, 1985·Archives of Surgery·R J GorisJ S Gimbrère
Jan 1, 1985·International Journal of Cardiology·B StrasbergJ Agmon
Oct 1, 1983·American Heart Journal·A SchwartzK Chatterjee
Jul 13, 1995·The New England Journal of Medicine·S N SinghD Lazzeri
Apr 1, 1995·European Heart Journal·Z Y HouR L Woosley
May 1, 1995·Annals of Internal Medicine·P J Podrid
Aug 1, 1993·British Journal of Clinical Pharmacology·P T PollakS G Carruthers
Jan 1, 1996·Journal of the American College of Cardiology·J H LevineR L Woosley
Aug 1, 1996·Southern Medical Journal·A Kumar
Mar 26, 1998·The American Journal of Cardiology·H F ClemoK A Ellenbogen
Jul 29, 1998·Intensive Care Medicine·L DonaldsonJ S Thomas
Sep 3, 1998·Chest·D Brathwaite, C Weissman
Oct 15, 1998·Anaesthesia·M H Nathanson, N M Gajraj
Sep 16, 2000·Intensive Care Medicine·H KnotzerW Hasibeder
Mar 29, 2001·Intensive Care Medicine·M Hughes, A Binning
Apr 20, 2001·Acta Anaesthesiologica Scandinavica·A MayrW Hasibeder
Jun 8, 2001·Critical Care Medicine·G Delle KarthG Heinz
Oct 26, 2001·Japanese Journal of Pharmacology·A SugiyamaK Hashimoto
Feb 11, 2003·Critical Care Medicine·Andreas MayrWalter Hasibeder
Citations
Nov 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Mengalvio E SleeswijkJan G Zijlstra
Jun 13, 2008·Biopharmaceutics & Drug Disposition·Leos FuksaStanislav Micuda
Aug 26, 2009·Journal of Intensive Care Medicine·Martin W Dünser, Walter R Hasibeder
Mar 7, 2008·Journal of Intensive Care Medicine·Mengalvio E SleeswijkJan G Zijlstra
Mar 27, 2020·BMJ Open·Liam Joseph O'BryanPeter J Watkinson
Jul 23, 2021·Critical Care : the Official Journal of the Critical Care Forum·Laura DrikiteMark Corbett