PMID: 602316Nov 15, 1977Paper

High-dosage glucocorticoid therapy in acute heart infarct and in cardiogenic shock

Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete
H Krosch, J Schäbitz

Abstract

40 patients with cardiogenic shock in consequence of contractility insufficiency of the heart were treated with high doses of prednisolon for short time. In 10 cases a good result of the treatment was to be seen so that the lethality quota was smaller than that of a reference group of the same age. The pharmacodynamic effect is seen in an improvement of the micro-circulation by a peripheric vasodilatation. 10 patients with acute myocardial infarction got a therapy with glucocorticoid combined with a treatment with anti-coagulants during the first both weeks. In this connection modern experimental examinations of animals are discussed which showed that glucocorticoides improve the anoxy tolerance of the heart muscle cell.

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