High dose adenosine stress echocardiography for noninvasive detection of coronary artery disease

Journal of the American College of Cardiology
A D Djordjevic-DikicV Kanjuh

Abstract

The aim of this study was to assess the tolerability and incremental diagnostic value of high adenosine doses in stress echocardiography testing in patients with coronary artery disease (CAD). In comparison with other pharmacologic stress echocardiography tests, standard dose adenosine stress has sub-optimal sensitivity for detecting milder forms of CAD. Adenosine stress echocardiography was performed in 58 patients using a starting dose of 100 micrograms/kg body weight per min over 3 min followed by 140 micrograms/kg per min over 4 min (standard dose). If no new wall motion abnormality appeared, the dose was increased to 200 micrograms/kg per min over 4 min (high dose). All patients underwent coronary angiography. Significant CAD was defined as > or = 50% diameter stenosis in at least one major coronary artery. Thirty-three patients had one-vessel and seven had multivessel CAD. Coronary angiographic findings were normal in 18 patients. The high adenosine dose caused a slight but significant increase over baseline values in rate-pressure product. Limiting side effects occurred in two patients during the standard dose protocol and in one patient receiving the high dose regimen. The test was stopped in 30 patients after the stand...Continue Reading

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Citations

Jul 15, 2005·The International Journal of Cardiovascular Imaging·Yoshinori NoguchiJohn B Wong
Jul 15, 2005·The International Journal of Cardiovascular Imaging·Eugenio Picano
Mar 25, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nowell M Fine, Patricia A Pellikka
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Aug 2, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tsutomu TakagiJunichi Yoshikawa

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