High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A S FreedmanL M Nadler

Abstract

The role for high-dose therapy and autologous stem-cell transplantation in mantle-cell lymphoma (MCL) is unknown. We retrospectively analyzed patients with chemosensitive disease who underwent high-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation (ABMT) for MCL in first remission, as well as following relapse from conventional therapy. Between August 1985 and April 1996, 28 patients underwent ABMT using a uniform ablative regimen with cyclophosphamide and total-body irradiation (TBI) and a bone marrow-purging regimen. Re-review of original tissue demonstrated that all patients had morphologic, phenotypic, and genotypic characteristics of MCL. MCL was the original diagnosis in 21 patients, whereas seven patients had a prior diagnosis of diffuse small cleaved-cell lymphoma. Twenty patients received multiple regimens before ABMT, while eight underwent ABMT in first complete remission (CR)/partial remission (PR) following CHOP induction. At bone marrow harvest, only 18% of patients were in CR and overt BM infiltration was present in 57%. Following cyclophosphamide/TBI, no treatment-related deaths were seen. Nineteen of 28 patients have relapsed at a median time of 21 months (r...Continue Reading

Citations

Feb 16, 2000·Bone Marrow Transplantation·D DecaudinC Gisselbrecht
Dec 21, 2000·Current Oncology Reports·C S Portlock
Jul 9, 2003·British Journal of Haematology·Christian BognerThomas Decker
Jun 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigScott H Kaufmann
Sep 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E Witzig
Jul 9, 2005·Expert Review of Anticancer Therapy·Johannes DrachHannes Kaufmann
Feb 3, 2007·Current Opinion in Oncology·Yvette L Kasamon
Feb 26, 2008·Leukemia & Lymphoma·Saar Gill, David Ritchie
Oct 30, 2009·Leukemia & Lymphoma·Oliver WeigertMartin Dreyling
Apr 13, 2010·Bone Marrow Transplantation·C NabhanJ Mehta
Jun 21, 2019·Current Hematologic Malignancy Reports·James N Gerson, Stefan K Barta
Oct 3, 2002·British Journal of Haematology·Edward A WilsonI Grant McQuaker
Jul 10, 1999·Current Opinion in Hematology·R G Bociek, J O Armitage
Aug 2, 2003·European Journal of Haematology·Niels S AndersenUNKNOWN Nordic Lymphoma Group
Jun 10, 2008·Current Opinion in Hematology·Mitchell R Smith
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter MartinJohn P Leonard
Sep 1, 2007·Journal of Oncology Practice·David J Straus
Jul 15, 2018·Journal of Experimental & Clinical Cancer Research : CR·Haige YeMichael L Wang
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Orion M HowardMargaret A Shipp
May 25, 2004·Leukemia & Lymphoma·Robert Marcus
Feb 13, 2002·Bone Marrow Transplantation·A M GianniUNKNOWN Michelangelo Cooperative

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