High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56+ natural killer cell lymphomas

Leukemia & Lymphoma
K TakenakaM Harada

Abstract

CD56+ natural killer (NK) cell lymphomas occur frequently in the nasal and nasopharyngeal regions and carry a poor prognosis. We have studied seven cases with NK-cell lymphomas. These lymphomas showed the following immunophenotype: CD56+, CD2+, sCD3- and Epstein-Barr virus-encoded small RNAs (EBERs)+. Six patients had localized (stage I or II) disease involving the nasopharyngeal region, while one had stage III disease. One patient with stage I disease achieved a complete remission (CR) after treatment with involved-field irradiation, but subsequently relapsed and died. The remaining six patients received combination chemotherapy as primary treatment: five patients with localized stage I or II disease and one patient with advanced stage III disease. Responses to initial chemotherapy were generally poor. These six patients received a variety of salvage chemotherapy regimens, but never achieved a CR. Subsequently, four of six patients showed a highly aggressive clinical course and died of disseminated disease within 1 year from the diagnosis. Three of six patients received high-dose chemotherapy supported by syngeneic, autologous or allogeneic peripheral blood stem cell transplantation. Two of the three transplant patients achiev...Continue Reading

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Citations

Nov 4, 2009·Leukemia & Lymphoma·Holbrook Kohrt, Ranjana Advani
Nov 26, 2010·International Journal of Hematology·Yok-Lam Kwong
Aug 5, 2003·International Journal of Hematology·Kazuo Oshimi
Jul 14, 2009·International Journal of Clinical Oncology·Yasuaki HarabuchiHideyuki Ishii
Jul 26, 2006·Digestive Diseases and Sciences·Catherine RongeyJoseph Murray
Jan 10, 2006·Bone Marrow Transplantation·R SuzukiUNKNOWN NK-cell Tumor Study Group
Jun 7, 2013·The Journal of Laryngology and Otology·J WangS-L Wang
May 2, 2019·Frontiers in Pediatrics·Yasuaki HarabuchiTakumi Kumai
Apr 6, 2007·The Tohoku Journal of Experimental Medicine·Hisayuki YokoyamaTakeshi Sasaki
Jul 12, 2002·Hematological Oncology
Apr 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P CorradiniS Tura

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