Abstract
CD56+ natural killer (NK) cell lymphomas occur frequently in the nasal and nasopharyngeal regions and carry a poor prognosis. We have studied seven cases with NK-cell lymphomas. These lymphomas showed the following immunophenotype: CD56+, CD2+, sCD3- and Epstein-Barr virus-encoded small RNAs (EBERs)+. Six patients had localized (stage I or II) disease involving the nasopharyngeal region, while one had stage III disease. One patient with stage I disease achieved a complete remission (CR) after treatment with involved-field irradiation, but subsequently relapsed and died. The remaining six patients received combination chemotherapy as primary treatment: five patients with localized stage I or II disease and one patient with advanced stage III disease. Responses to initial chemotherapy were generally poor. These six patients received a variety of salvage chemotherapy regimens, but never achieved a CR. Subsequently, four of six patients showed a highly aggressive clinical course and died of disseminated disease within 1 year from the diagnosis. Three of six patients received high-dose chemotherapy supported by syngeneic, autologous or allogeneic peripheral blood stem cell transplantation. Two of the three transplant patients achiev...Continue Reading
References
Jul 1, 1992·Human Pathology·K F WongM M Cheung
Oct 1, 1990·Human Pathology·F C HoR K Khoo
Mar 1, 1995·The American Journal of Surgical Pathology·S NakamuraE Katoh
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W H WilsonB D Cheson
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R LiangF C Ho
Jan 1, 1996·The American Journal of Surgical Pathology·E S JaffeF C Ho
Apr 20, 1996·Lancet·T TeshimaK Ohshima
Jan 1, 1997·Bone Marrow Transplantation·R LiangE Chiu
Apr 1, 1997·Leukemia & Lymphoma·K OhnumaH Kikuta
Jun 1, 1997·British Journal of Haematology·Y L KwongF C Ho
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M CheungR K Ngan
Jul 23, 1998·Bone Marrow Transplantation·A TakamiT Matsuda
Feb 27, 1999·Leukemia & Lymphoma·H Y MukaiT Nagasawa
Jul 22, 1999·Bone Marrow Transplantation·Y NawaM Harada
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G E KimB S Kim
Citations
Nov 4, 2009·Leukemia & Lymphoma·Holbrook Kohrt, Ranjana Advani
Apr 23, 2015·Leukemia & Lymphoma·Christopher P FoxAnna Sureda
May 24, 2011·Leukemia & Lymphoma·Daisuke EnnishiMitsune Tanimoto
Aug 16, 2005·British Journal of Haematology·Naoko MurashigeKazuo Oshimi
Nov 26, 2010·International Journal of Hematology·Yok-Lam Kwong
Aug 5, 2003·International Journal of Hematology·Kazuo Oshimi
Jul 14, 2009·International Journal of Clinical Oncology·Yasuaki HarabuchiHideyuki Ishii
Mar 21, 2006·Bone Marrow Transplantation·H J KimW S Kim
Sep 22, 2009·Bone Marrow Transplantation·Y-L Kwong
Jul 26, 2006·Digestive Diseases and Sciences·Catherine RongeyJoseph Murray
Jan 10, 2006·Bone Marrow Transplantation·R SuzukiUNKNOWN NK-cell Tumor Study Group
Jun 7, 2013·The Journal of Laryngology and Otology·J WangS-L Wang
May 2, 2019·Frontiers in Pediatrics·Yasuaki HarabuchiTakumi Kumai
Nov 26, 2008·Blood·Wing-yan AuUNKNOWN International Peripheral T-Cell Lymphoma Project
Nov 12, 2005·Journal of Neuro-oncology·Neal LutherTheodore H Schwartz
Dec 2, 2009·International Journal of Hematology·Yasuo MoriKoichi Akashi
Mar 19, 2004·Australasian Radiology·Susan LoongKhai Mun Lee
Apr 6, 2007·The Tohoku Journal of Experimental Medicine·Hisayuki YokoyamaTakeshi Sasaki
Apr 24, 2010·Medical Oncology·Meng LiWanming Da
Mar 22, 2018·Medicine·Wan-Lin ZhangLian-He Yang
Jul 12, 2002·Hematological Oncology
Apr 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P CorradiniS Tura