High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: a preliminary report

Gynecologic Oncology
P B PaniciS Mancuso

Abstract

One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected (2/21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.

References

Jun 1, 1987·British Journal of Obstetrics and Gynaecology·F KirstenM Friedlander
Jan 1, 1986·Cancer·G S MontanaL Shemanski
Jan 1, 1984·Annals of Internal Medicine·R F OzolsR C Young

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Citations

May 4, 1999·Seminars in Surgical Oncology·H N Nguyen, S R Nordqvist
Jul 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S J Kim
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C KainzG Breitenecker
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Benedetti-PaniciS Mancuso
Sep 25, 2002·Critical Reviews in Oncology/hematology·P O WitteveenM A van Eijkeren
May 1, 1996·Obstetrical & Gynecological Survey·D Z Edelmann, S O Anteby
Feb 19, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hae Nam LeeJong Sup Park
Aug 30, 2008·Surgical Oncology Clinics of North America·Takeshi MaruoYonson Ku
Mar 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P Benedetti Panici, F Bellati
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Mar 18, 1999·Hematology/oncology Clinics of North America·K GrevenR Lanciano
Aug 2, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jazmin M Pérez-RojasJosé Pedraza-Chaverri
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Sep 15, 2004·Critical Reviews in Oncology/hematology·Rosa TambaroSandro Pignata
Jul 25, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dae Woo LeeHae Nam Lee
Sep 2, 2020·The Journal of International Medical Research·Shu-Li YangYu-Mei Wu
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfonso Duenas-GonzalezAlejandro Mohar

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