Abstract
We designed a phase II study to determine whether induction chemotherapy (CT) consisting of leucovorin, vincristine, methotrexate, doxorubicin, and cyclophosphamide (LOMAC) followed by high-dose intensification chemotherapy (ICT) with cyclophosphamide, thiotepa, and autologous stem cell rescue (ASCR) could increase the complete response (CR) rate and survival in women with stage IV breast cancer. Twenty-nine women were enrolled on study; 16 patients had received prior adjuvant chemotherapy and no patient had received chemotherapy for stage IV disease. Two patients were found to be ineligible and excluded from further analysis. Of the 27 patients treated, four (15%) obtained a CR and 15 (56%) a partial response (PR) after LOMAC induction, for an overall response rate of 70%. Of the 22 patients treated with ICT, 12 patients had a CR, and nine were in PR after induction and converted to CR after ICT. The toxicities included nausea/vomiting, mucositis, diarrhea, dermatitis, alopecia, and infections secondary to neutropenia. The 1-year survival is 60%; the median has not yet been reached. The time to treatment failure for patients on study is 10 months. The treatment approach of ICT and ASCR following induction chemotherapy can lead...Continue Reading
Citations
Apr 1, 1996·American Journal of Clinical Oncology·M deMagalhaes-SilvermanE D Ball
Jan 1, 1996·Stem Cells·B E Brockstein, S F Williams
Apr 4, 2000·Bone Marrow Transplantation·T DemirerH Koç
Sep 1, 2000·Bone Marrow Transplantation·L E DamonC A Linker
Mar 30, 2001·Bone Marrow Transplantation·C SolanoJ García-Conde
Jan 18, 2002·Stem Cells·Manfred HenselAnthony D Ho
May 19, 2006·Bone Marrow Transplantation·D T Vogl, E A Stadtmauer
Jun 16, 2006·Clinical Trials : Journal of the Society for Clinical Trials·Musa Mayer
Nov 27, 2007·Bone Marrow Transplantation·P BironH Curé
Dec 10, 2009·International Journal of Hematology·Yee Chung ChengNaoto T Ueno
Nov 1, 1991·Journal of Surgical Oncology·D DebonisL R Hill
Mar 15, 1994·Cancer·G SomloS Nagasawa
Jan 1, 1992·Journal of Hematotherapy·S E MyersR B Geller
Apr 1, 1994·Cancer·R E LamarJ D Hainsworth
Jan 1, 1996·Breast Cancer Research and Treatment·W A FranklinR B Jones
Apr 15, 1994·Cancer·F R DunphyG N Hortobagyi
Jul 1, 1994·Human Gene Therapy·J A O'ShaughnessyD Kohler
Dec 1, 1994·Human Gene Therapy·A B DeisserothR Champlin
Mar 14, 2000·Bone Marrow Transplantation·A BasheyA D Ho
Jun 1, 2002·Bone Marrow Transplantation·A C BraudP Viens
Jun 1, 1994·Australian and New Zealand Journal of Medicine·D KotasekA Bolton
Aug 17, 2002·Drugs & Aging·Renee M GerreroEdward A Stadtmauer
Sep 30, 2000·Stem Cells·D V JonesG Fyfe
May 7, 2003·Bone Marrow Transplantation·T DemirerH Akan
Dec 1, 1991·Breast Cancer Research and Treatment·J A Neidhart
Apr 13, 2000·The New England Journal of Medicine·E A StadtmauerJ H Glick
Jan 14, 2000·Journal of Hematotherapy & Stem Cell Research·M GoernerW M Gallmeier
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William P PetersDavid D Hurd
Jan 1, 1994·Cancer·G SomloI Sniecinski
Sep 1, 1991·The Journal of Legal Medicine·F P James
Oct 17, 1998·Breast Cancer Research and Treatment·K H YehY C Chen
Feb 14, 1998·Journal of the National Cancer Institute·J ZujewskiJ Abrams
Apr 13, 1999·American Journal of Clinical Oncology·L S SchwartzbergC D Buckner
Jan 1, 1994·Medical Oncology·G SpitzerD R Adkins
Mar 7, 2003·Bone Marrow Transplantation·K A SchulmanJ H Glick
Jan 1, 1995·Breast Cancer Research and Treatment·P FumoleauM Van Glabbeke
Sep 25, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·K MargolinJ H Doroshow