High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy

Muscle & Nerve
T H BrannaganDouglas E Gladstone

Abstract

Patients with multifocal motor neuropathy (MMN) respond to intravenous immune globulin (IVIg) and cyclophosphamide, although the benefit is not sustained. High-dose cyclophosphamide can induce a remission in patients with autoimmune diseases, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We describe a patient with refractory MMN who improved with high-dose cyclophosphamide (50 mg/kg for 4 days) without stem cell rescue. Following treatment she discontinued IVIg. At a 6-month examination, her strength had improved and she had regained the ability to write. High-dose cyclophosphamide may be a successful treatment for patients with MMN refractory to other therapies.

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Citations

Jan 16, 2007·Current Neurology and Neuroscience Reports·Thomas B Toothaker, Thomas H Brannagan
Mar 13, 2008·Current Treatment Options in Neurology·Ryuji Kaji
Nov 21, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andreas J SteckSusanne Renaud
Aug 9, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Fumitaka ShimizuTakashi Kanda
Feb 9, 2011·Expert Opinion on Biological Therapy·Filip Eftimov, Ivo N Van Schaik
Jun 30, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Suraj Ashok Muley, Gareth J Parry
Sep 15, 2007·Journal of Neuroimmunology·Douglas E GladstoneThomas H Brannagan
Mar 5, 2015·The Cochrane Database of Systematic Reviews·T UmapathiJean-Marc Léger

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