PMID: 6538488Feb 1, 1984Paper

High-dose cytosine arabinoside in multiple myeloma

European Journal of Cancer & Clinical Oncology
H KantarjianR Alexanian

Abstract

In 14 patients with advanced refractory multiple myeloma, the effect of high-dose cytosine arabinoside (ara-C) administration was evaluated. There was one partial remission among 13 evaluable patients who received 2 g/m2 intravenously over 2 hr every 12 hr, for a total of 2-8 g/m2 per course, repeated every 3-4 weeks. Myelosuppression constituted the dose-limiting toxicity, causing two treatment-related deaths from infection and bleeding. Prior extensive therapy, a low percentage of cells in S phase and low levels of intracellular ara-CTP accumulation in the bone marrow could explain the resistance of myeloma to this treatment.

References

Dec 1, 1977·Cancer·R AlexanianJ Weick
May 1, 1975·Annals of Internal Medicine·W B Kremer
Oct 1, 1980·The American Journal of Medicine·E Frei, G P Canellos

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Citations

Sep 1, 1985·The Journal of Applied Bacteriology·J Harvey, A Gilmour
Jan 1, 1990·Society for Applied Bacteriology Symposium Series·A Gilmour, J Harvey
Jan 1, 1989·Medical and Pediatric Oncology·W J SmithP J Zekan
Mar 10, 2021·British Journal of Haematology·Alexis ClaudelBertrand Arnulf

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