High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study.

Journal of Critical Care
Philipp SchultzThomas Köhler

Abstract

Hemoadsorption with CytoSorb® offers a possible therapeutic approach in septic shock, but modes of application and dosing are still undetermined. Data from surgical patients with septic shock, treated with hemoadsorption adjunctive to renal replacement therapy were analyzed retrospectively. The 28-day mortality was compared to predicted mortality. In 70 patients (70.6 ± 13.3 years), hemoadsorption was applied for 85.6 ± 53.8 h. The APACHE ll (30.2 ± 6.3) calculated to a predicted mortality of 73.3%, while the observed mortality was significantly lower (50%, p < 0.05). The amount of blood purified was higher in survivors than in non-survivors (8.5 ± 4.4 vs. 6.1 ± 3.6 l/kgBW, p = 0.017). We identified three clusters of <6 l/kgBW, 6-13 l/kgBW and ≥ 13 l/kgBW with a linear dose-response relation between blood purification volume and survival, which was best in the highest volume cluster (83.3%; p = 0.045). The application of CytoSorb® seems to be effective in various conditions of septic shock. In a cohort of most severely ill patients the observed mortality was lower than predicted and decreased linearly with blood purification volumes inadvertently exceeding 6 l/kg BW. These results suggest that hemoadsorption might improve survi...Continue Reading

References

Aug 9, 2005·The American Journal of Medicine·Yvonne Patricia YmpaJean-Louis Vincent
Mar 7, 2012·Microbiology and Molecular Biology Reviews : MMBR·Jennifer R TisoncikMichael G Katze
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Mar 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Raghavan MuruganUNKNOWN Biological Markers for Recovery of Kidney (BioMaRK) Study Investigators
Jan 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Eric D MorrellKenneth R Hallows
Dec 10, 2015·Critical Care Medicine·Kai SingbartlJohn A Kellum
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Mar 28, 2017·Critical Care : the Official Journal of the Critical Care Forum·Klaus KogelmannMatthias Drüner
Jun 8, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sigrun FrieseckeAxel Nierhaus
Aug 6, 2017·Intensive Care Medicine Experimental·Anthony BonaviaKai Singbartl
Sep 9, 2017·Clinical Hemorheology and Microcirculation·Dietrich HenzlerThomas Köhler
Sep 16, 2017·Critical Care Medicine·Carmen Andrea PfortmuellerJoerg Christian Schefold
Oct 25, 2017·Intensive Care Medicine Experimental·Carmen Andrea PfortmuellerJoerg C Schefold
May 8, 2018·Intensive Care Medicine Experimental·Benjamin MalardJohn A Kellum
Sep 3, 2018·Blood Purification·Jingxiao ZhangClaudio Ronco
Sep 17, 2018·Blood Purification·Claudia GemelliStefano Faenza
Dec 14, 2018·The International Journal of Artificial Organs·Christina KönigAxel Nierhaus
May 16, 2019·Seminars in Thoracic and Cardiovascular Surgery·Thomas G GleasonJoseph B Zwischenberger
Sep 12, 2019·Blood Purification·Stephan HarmJens Hartmann
Feb 28, 2020·World Journal of Critical Care Medicine·Yatin MehtaArun Raizada
Mar 25, 2020·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC III Investigators
Apr 7, 2020·The Thoracic and Cardiovascular Surgeon·Ali AkilStefan Fischer

❮ Previous
Next ❯

Citations

Aug 22, 2021·Journal of Critical Care·Alexander Supady, Daniel Duerschmied

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved