High-Dose DHA Has More Profound Effects on LDL-Related Features Than High-Dose EPA: The ComparED Study

The Journal of Clinical Endocrinology and Metabolism
Janie AllaireBenoît Lamarche

Abstract

Supplementation with high-dose docosahexaenoic acid (DHA) increases serum low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations more than high-dose eicosapentaenoic acid (EPA). The mechanisms underlying this difference are unknown. To examine the phenotypic change in LDL and mechanisms responsible for the differential LDL-C response to EPA and DHA supplementation in men and women at risk of cardiovascular disease. In a double-blind, controlled, crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three treatment phases: phase 1, 2.7 g/d of EPA; phase 2, 2.7 g/d of DHA; and phase 3, 3 g/d of corn oil. All supplements were provided as three 1-g capsules for a total of 3 g/d. The 10-week treatment phases were separated by a 9-week washout period. In vivo kinetics of apolipoprotein (apo)B100-containing lipoproteins were assessed using primed-constant infusion of deuterated leucine at the end of each treatment in a subset of participants (n = 19). Compared with EPA, DHA increased LDL-C concentrations (+3.3%; P = 0.038) and mean LDL particle size (+0.7 Å; P < 0.001) and reduced the proportion of small LDL (-3.2%; P < 0.01). Both EPA and DHA decreased pro...Continue Reading

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Citations

May 20, 2020·Biological Chemistry·Shahin Alizadeh-FanalouMohsen Khosravi
Jun 20, 2020·Archives of Endocrinology and Metabolism·Telma Angelina Faraldo CorrêaMarcelo Macedo Rogero
May 21, 2020·Nutrients·Maria Pia AdorniNicola Ferri
Oct 8, 2020·Current Opinion in Lipidology·Anna WolskaAlan T Remaley
Mar 12, 2021·Atherosclerosis·Sang-Ho JoKwang Kon Koh
Mar 21, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Zhenyu ChuMiao Hou

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