PMID: 11319287Apr 25, 2001Paper

High-dose epirubicin plus docetaxel at standard dose with lenograstim support as first-line therapy in advanced breast cancer

American Journal of Clinical Oncology
A Milla-SantosV Solano

Abstract

On the basis of preclinical and clinical data, we designed a phase II study to determine the efficacy and feasibility of high-dose epirubicin plus docetaxel (Taxotere) with lenograstim support, as first-line therapy for patients with advanced breast cancer. Patients with histologic evidence of metastatic breast cancer, without previous chemotherapy, adequate organ functions, Eastern Cooperative Oncology Group performance status less than 2, and signed informed consent entered in the trial. Treatment consisted of premedication the day before the treatment day for 3 consecutive days (dexamethasone 16 mg o.r. and 5-HT3 antagonists). On the treatment day 1, epirubicin 130 mg/m2 was administered as a 15-minute intravenous infusion followed 1 hour later by 1-hour intravenous infusion of docetaxel 100 mg/m2. Cycles were repeated every 21 days, for a maximum of 8 cycles. Lenograstim (5 microg/kg, s.c.) was started 48 hours later (day 4) and was given daily for 10 consecutive days. Response evaluation was made after the third cycle was applied, following World Health Organization criteria. Responding patients received five additional cycles. Median time to progression and survival were calculated according to the Kaplan-Meier method. A ...Continue Reading

References

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·T HickishR C Coombes
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Italian Multicentre Breast Study with EpirubicinC Intini
Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Hryniuk, H Bush

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Citations

Jul 19, 2003·Breast Cancer Research and Treatment·Jean-Marc A Nabholtz
Oct 24, 2001·Current Opinion in Oncology·A C Wolff
Aug 19, 2004·Cancer Chemotherapy and Pharmacology·E EspinosaM González Barón
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SandströmM O Karlsson
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri RochéBernard Asselain
Oct 18, 2007·British Journal of Cancer·T GamucciL Meliffi
Apr 20, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Stefan Glück

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