Jun 29, 2013

High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine

Translational Research : the Journal of Laboratory and Clinical Medicine
Vesna Borovnik-LesjakRaúl J Gazmuri


We investigated the metabolic and functional myocardial effects of erythropoietin (EPO) administered during resuscitation from cardiac arrest using an open-chest pig model of ventricular fibrillation and resuscitation by extracorporeal circulation, after having reported in rats a reversal of postresuscitation myocardial dysfunction associated with activation of mitochondrial protective pathways. Ventricular fibrillation was induced in 16 male domestic pigs and left untreated for 8 minutes, after which extracorporeal circulation was started and maintained for 10 additional minutes, adjusting the extracorporeal flow to provide a coronary perfusion pressure of 10 mmHg. Defibrillation was accomplished and the extracorporeal flow was adjusted to secure a mean aortic pressure of 40 mmHg or greater during spontaneous circulation for up to 120 minutes. Pigs were randomized 1:1 to receive EPO (1200 U/kg) or 0.9% NaCl before starting extracorporeal circulation. Severe postresuscitation myocardial dysfunction developed in both groups. However, recovery of myocardial function-comparing baseline with 120 minutes postresuscitation-was better in pigs treated with EPO than NaCl, as shown for left ventricular ejection fraction (from 45 ± 8% to ...Continue Reading

  • References33
  • Citations10


Mentioned in this Paper

CNOT8 gene
Metabolic Process, Cellular
Ventricular Fibrillation
Biochemical Pathway
Calcium [EPC]
Entire Great Cardiac Vein
Body Parts - Cannula

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