PMID: 15222725Jun 30, 2004Paper

High-dose exposure to valsartan with suicidal intention

International Journal of Clinical Pharmacology and Therapeutics
B KumbasarM Ayer

Abstract

Valsartan is a strong angiotensin receptor inhibitor specific for the angiotensin I receptor, which has been proven safe and well-tolerated in clinical trials. We were able to confirm its safety and tolerability in a case of high-dose exposure to valsartan with suicidal intention. A 25-year-old, fully conscious, female patient was brought to our hospital by relatives on July 24, 2001, at 9:15 p.m. following intake of a high dose of valsartan. It was established that she had taken 28 Diovan 80 mg tablets (2.24 g) 5 hours before admission to the hospital. Her clinical condition at the time of admission was good and did not deteriorate after admission. During the follow-up, her blood pressure never fell below 90/60 mmHg. The only complaint she had were painful muscle cramps which, with only supportive therapy, disappeared spontaneously over 2 days, and her blood pressure also returned to normal during this period. This report demonstrates the effect/side effect profile of valsartan when taken at a high dose, not achievable in a clinical trial.

Citations

Aug 6, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gianfranco ParatiThomas Mengden
Dec 15, 2010·Expert Opinion on Drug Safety·Roberto Fogari, Annalisa Zoppi

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