High-dose flecainide is the most effective treatment of fetal supraventricular tachycardia

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Brigitte StrizekU Gembruch

Abstract

Fetal tachyarrhythmia can lead to fetal hydrops due to heart failure. Flecainide is often considered as second-line therapy when digoxin monotherapy fails, which is more likely in hydropic fetuses. Time to conversion to sinus rhythm (SR) is critical in cases presenting with hydrops. The aim of this study was to evaluate the efficacy and time to conversion to SR of transplacental treatment, especially flecainide. This is a retrospective observational study of 46 fetuses with fetal tachyarrhythmia. Treatment was either flecainide (n = 28, 60.9%), digoxin+flecainide combination (n = 4, 8.7%), or digoxin (n = 10, 21.7%). In 4 fetuses (8.7%), no treatment was necessary. In our study population, 26 of the 32 fetuses (81.2%) that were treated with flecainide as a first-line therapy (flecainide or digoxin+flecainide) converted to SR. The median time to conversion to SR was 3 days (range 1-7 days) with flecainide monotherapy and 11.5 days (range 3-14 days) with a combination therapy. Seventy-two percent (13/18) of hydropic fetuses and 90% (9/10) of nonhydropic fetuses converted to SR when treated with flecainide monotherapy. There was no statistical difference in rates of conversion to SR in hydropic and nonhydropic fetuses (P = .37) or...Continue Reading

References

Jan 1, 1991·British Heart Journal·L D AllanK Priestley
Mar 1, 1997·Pediatric Cardiology·J M SimpsonG K Sharland
Mar 17, 1999·Heart·J M Simpson, G K Sharland
Apr 14, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R P SchadeE J Meijboom
Jun 14, 2000·Circulation·M A OudijkE J Meijboom
Mar 6, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M KrappU Germer
May 1, 1991·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M HansmannD A Redel
Aug 3, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M A OudijkE J Meijboom
Dec 22, 2004·Prenatal Diagnosis·Jean-Claude Fouron
Feb 5, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Olus Api, Julene S Carvalho
Jul 30, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Trisha V VigneswaranJohn M Simpson

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Citations

Jan 25, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ali EkizGokhan Yildirim
May 13, 2017·Current Medical Research and Opinion·Vasiliki KatsiDimitris Tousoulis
Jul 20, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Keiko UedaUNKNOWN ; on behalf of Japan Fetal Arrhythmia Group
Aug 24, 2017·Prenatal Diagnosis·Garick D HillMichele A Frommelt
Dec 17, 2017·Journal of the American Heart Association·Tarek AlsaiedAllison A Divanovic
May 29, 2019·Expert Opinion on Pharmacotherapy·Georgios GeorgiopoulosChristodoulos Stefanadis
Feb 27, 2020·Journal of Cardiovascular Electrophysiology·Edward T O'LearyDouglas Y Mah
Apr 30, 2020·Current Medical Research and Opinion·Theodora A ManolisAntonis S Manolis
Feb 14, 2020·Italian Journal of Pediatrics·Shi-Min Yuan, Zhi-Yang Xu
Mar 8, 2017·Current Treatment Options in Cardiovascular Medicine·Bridget B Zoeller

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