High-dose glucocorticoids increase serum levels of soluble IL-6 receptor alpha and its ratio to soluble gp130: an additional mechanism for early increased bone resorption

European Journal of Endocrinology
Andrea DovioAlberto Angeli

Abstract

Glucocorticoids (GCs) at pharmacological doses stimulate bone resorption. Mechanisms of this action are unclear. The osteoclastogenic cytokine interleukin (IL)-6 acts through an oligomeric receptor consisting of two subunits, gp80 (or IL-6 receptor alpha, IL-6Ralpha) and gp130; both exist in membrane and soluble forms. Soluble IL-6Ralpha (sIL-6Ralpha) enhances, while sgp130 inhibits IL-6 signalling. In vitro, GCs enhance many effects of IL-6 by up-regulation of IL-6Ralpha. The aim of the present study was to assess acute changes of IL-6 system in the peripheral blood of patients given high-dose GCs. Serum levels of IL-6, sIL-6Ralpha, sgp130 and bone turnover markers were assessed before and each day during treatment in 24 multiple sclerosis (MS) patients undergoing high-dose (prednisolone, 15 mg/kg per day), short-term (3 to 5 days) intravenous GC therapy for relapse at the Regional Multiple Sclerosis Centre. An immediate and marked fall of osteocalcin and an early increase of C-terminal telopeptide of type I collagen were already noticed at day 2 (P < 0.001 and P < 0.02, respectively); both became more apparent in the subsequent days. IL-6 was always below or near the detection limit of our ELISA. sgp130 showed a slight increa...Continue Reading

Citations

Jun 15, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E CanalisJ P Bilezikian
Nov 29, 2012·Calcified Tissue International·Jef VanderoostG Harry van Lenthe
May 24, 2011·Journal of Osteoporosis·Vit Zikan
Feb 25, 2009·Expert Opinion on Drug Safety·Liron Caplan, Kenneth G Saag
Oct 26, 2011·Rheumatic Diseases Clinics of North America·Michael Maricic
Mar 5, 2013·Clinical Endocrinology·Miklós Tóth, Ashley Grossman
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kent Søe, Jean-Marie Delaissé
Jul 6, 2014·Cytokine·Janina WolfChristoph Garbers
Jan 8, 2014·Korean Journal of Orthodontics·Ryuichi KuniiKazutaka Kasai
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Gherardo MazziottiJohn P Bilezikian
Mar 20, 2015·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Malay SarkarJasmin Khatana
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Apr 15, 2020·Nature Reviews. Endocrinology·Pojchong Chotiyarnwong, Eugene V McCloskey
Feb 26, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G Adami, K G Saag
Oct 28, 2019·Frontiers in Cell and Developmental Biology·Miriam CaffariniMonia Orciani
Jan 15, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Natalia Weare-RegalesRichard F Lockey
Dec 12, 2021·Journal of Cellular and Molecular Medicine·Aysa RezabakhshSamad Ghaffari
Dec 12, 2021·Clinical Pharmacokinetics·Elizabeth LeungNathaniel J Rhodes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.