High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome

Fertility and Sterility
J A LandJ L Evers

Abstract

To study the outcome in poor responders to three ampules (225 IU) of hMG per day in subsequent IVF treatment cycles in which six ampules (450 IU)of hMG per day were administered. Retrospective chart review. Academic tertiary center. Between January 1988 and May 1995, 126 poor response patients had a first treatment cycle on three ampules and a second cycle on six ampules of hMG per day. Numbers of follicles, oocytes, and embryos, and pregnancy rates. On six ampules, patients had significantly more follicles and oocytes. The number of embryos did not differ significantly. The pregnancy rate on six ampules were low (3.2% pregnancies per cycle started). Poor responders do not benefit from high-dose hMG stimulation; their reproduction outcome is poor.

Citations

Jan 20, 1998·Clinical Pharmacology and Therapeutics·M O KarlssonA Munafo
Aug 26, 1998·Journal of Assisted Reproduction and Genetics·D L HockE Kemmann
Jul 13, 1999·Human Reproduction·V Karande, N Gleicher
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enrico PapaleoAugusto Ferrari
Jul 11, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G AhmadR Gazvani
Nov 24, 2007·Journal of Assisted Reproduction and Genetics·D LoutradisA Antsaklis
Jun 23, 2009·Human Fertility : Journal of the British Fertility Society·Rita De Cássia Sávio FigueiraEdson Borges
Oct 2, 2009·Clinical Genetics·J P M Geraedts, G M W R De Wert
Apr 20, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ariel WeissmanDavid Levran
Dec 1, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Xiaoxia Chang, Jie Wu
May 1, 2015·Journal of Assisted Reproduction and Genetics·Antonio La MarcaSesh Kamal Sunkara
Jan 9, 1998·British Journal of Obstetrics and Gynaecology·A GorgyI L Craft
Jan 27, 1998·British Journal of Obstetrics and Gynaecology·K SharifM Afnan
Sep 14, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S Kupesic
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·Stephen D Keay
Feb 21, 2006·Human Reproduction·Anita KanPak Chung Ho
Mar 10, 2007·Human Reproduction Update·T A GelbayaL G Nardo
Jul 27, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C S Siristatidis, M P Hamilton
Mar 4, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marta DevesaPedro N Barri
Nov 27, 2010·Journal of Assisted Reproduction and Genetics·Amanda Souza SettiEdson Borges
Dec 14, 2011·Journal of Assisted Reproduction and Genetics·Eun Mi ChangWoo Sik Lee
Apr 1, 1999·Human Reproduction·J C DumoulinJ L Evers
Jun 19, 2007·Journal of Assisted Reproduction and Genetics·Luk Rombauts
Jul 29, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·János UrbancsekThomas Strowitzki
Feb 20, 2007·Annals of the New York Academy of Sciences·Stavroula BakaGeorge Creatsas
Feb 4, 2006·Clinical Obstetrics and Gynecology·William B Schoolcraft
Nov 17, 2007·Human Reproduction Update·B C J M FauserUNKNOWN Evian Annual Reproduction Workshop Group 2007
Mar 30, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jimmy E JadaonJohnny S Younis
May 28, 2013·Archives of Gynecology and Obstetrics·Mustafa KaraBetul Ozdemir
May 10, 2013·Journal of Assisted Reproduction and Genetics·Yong Soo HurJin Ho Lim
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
Oct 6, 2011·Human Fertility : Journal of the British Fertility Society·Lata KambleRoy Homburg

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