High-Dose Human Milk Feedings Decrease Oxidative Stress in Premature Infant

JPEN. Journal of Parenteral and Enteral Nutrition
Yimin ChenAloka L Patel

Abstract

Premature infants are susceptible to oxidative stress, increasing the risk for serious morbidities. High-dose human milk (HM) feedings decrease morbidity risks and may reduce oxidative stress in this population. The purpose of this study was to compare oxidative stress using serial urinary F2 -isoprostane concentrations in predominantly HM and preterm formula (PF)-fed premature infants over the first 21 days of life (DOL), while controlling for perinatal oxidative stress exposures including bovine-based human milk fortifier (HMF) or PF introduction to predominantly HM-fed infants. This was a quasi-experimental design that categorized 22 premature infants into mutually exclusive comparison groups based on exposure to HM and PF. Serial urine samples (before and after first feeding, and DOL 7, 14, and 21) were used to determine urine F2 -isoprostane concentrations measured by enzyme-linked immunosorbent assays. We analyzed data using Mann-Whitney U test, Wilcoxon rank test, and multilevel models. Comparing the predominantly HM-fed and predominantly PF-fed groups over time, median F2 -isoprostane concentrations decreased significantly in the predominantly HM group (P = .003) and increased significantly in the predominantly PF group...Continue Reading

References

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Citations

Jan 12, 2019·International Journal of Pediatrics·Pasqua Anna QuitadamoPierpaolo Cristalli
Feb 19, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Yasuaki Wada, Bo Lönnerdal
Jan 6, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Karishma KattiBarry Weinberger
Feb 25, 2021·International Journal of Pediatrics·Pasqua Anna QuitadamoAntonio Villani
Aug 7, 2021·Clinics in Perinatology·Isabelle Von Kohorn, Valerie Flaherman
Oct 16, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark A UnderwoodStephen Wedgwood

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